ArticleGut1999
Notable postnatal alterations in the myenteric plexus of normal human bowel.
Article in Gut, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- A phase 2a study investigating the effects of ritlecitinib on brainstem auditory evoked potentials and intraepidermal nerve fiber histology in adults with alopecia areata.Pharmacology research & perspectives · 2024Trial
- The junction between the midgut and hindgut co-localizes with the rectosigmoid junction.Journal of anatomy · 2026Article
- Associations between maternal exposure to per- and polyfluoroalkyl substances and functional constipation in children at 3 and 4 years: the Japan Environment and Children's Study.Environmental health and preventive medicine · 2026Article
- Three-Dimensional Imaging of the Enteric Nervous System in Human Pediatric Colon Reveals New Features of Hirschsprung's Disease.Gastroenterology · 2024Article
- Translational research in Hirschprung's disease at the National Children's Research Centre in Dublin.Pediatric surgery international · 2022Review
- A comprehensive review of functional dyspepsia in pediatrics.Clinical journal of gastroenterology · 2022Review
- Characterisation of parasympathetic ascending nerves in human colon.Frontiers in neuroscience · 2022Article
- A neural crest cell isotropic-to-nematic phase transition in the developing mammalian gut.Communications biology · 2021Article
- Genetic background-dependent abnormalities of the enteric nervous system and intestinal function in Kif26a-deficient mice.Scientific reports · 2021Article
- How Smooth Muscle Contractions Shape the Developing Enteric Nervous System.Frontiers in cell and developmental biology · 2021Article
- The role of gasotransmitters in neonatal physiology.Nitric oxide : biology and chemistry · 2020Review
- Weaning stress and gastrointestinal barrier development: Implications for lifelong gut health in pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2017Review
- Impaired intestinal barrier function and relapsing digestive disease: Lessons from a porcine model of early life stress.Neurogastroenterology and motility · 2017Review
- Early-life stress origins of gastrointestinal disease: animal models, intestinal pathophysiology, and translational implications.American journal of physiology. Gastrointestinal and liver physiology · 2015Review
- Bioengineering of physiologically functional intrinsically innervated human internal anal sphincter constructs.Tissue engineering. Part A · 2014Article
- Age-related gene expression analysis in enteric ganglia of human colon after laser microdissection.Frontiers in aging neuroscience · 2014Article
- Quantitative changes of nitrergic neurons during postnatal development of chicken myenteric plexus.Journal of Zhejiang University. Science. B · 2013Article
- Classification and diagnostic criteria of variants of Hirschsprung's disease.Pediatric surgery international · 2013Review
- Article
- Effect of ageing on colonic mucosal regeneration.World journal of gastroenterology · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNitric oxide is the most important transmitter in non-adrenergic non-cholinergic nerves in the human gastrointestinal tract. Impaired nitrergic innervation has been described in Hirschsprung's disease, hypertrophic pyloric stenosis, and intestinal neuronal dysplasia (IND). Recent findings indicate that hyperganglionosis, one of the major criteria of IND, is age dependent. However, information is scanty regarding the neurone density in normal human bowel in the paediatric age group.
aimsTo determine neurone density, morphology, and nitric oxide synthase distribution of the normal myenteric plexus at different ages during infancy and childhood.
methodsSpecimens were obtained from small bowel and colon in 20 children, aged one day to 15 years, at postmortem examination. Whole mount preparations were made of the myenteric plexus, which were subsequently stained using NADPH diaphorase histochemistry (identical to nitric oxide synthase) and cuprolinic blue (a general neuronal marker). The morphology of the myenteric plexus was described and the neurone density estimated.
resultsThe myenteric plexus meshwork becomes less dense during the first years of life. The density of ganglion cells in the myenteric plexus decreases significantly with age during the first three to four years of life. The NADPH diaphorase positive (nitrergic) subpopulation represents about 34% of all neurones in the myenteric plexus.
conclusionsThe notable decrease in neurone density in the myenteric plexus during the first years of life indicates that development is still an ongoing process in the postnatal enteric nervous system. Applied to the clinical situation, this implies that interpretation of enteric nervous system pathology is dependent on the age of the patient.
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