ArticleJournal of clinical microbiology1999
Coaggregation of Candida dubliniensis with Fusobacterium nucleatum.
Article in Journal of clinical microbiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 92 citations in OpenAlex.
- Review
- Supragingival microbiome variations and the influence ofJournal of oral microbiology · 2024Article
- Fungi-A Component of the Oral Microbiome Involved in Periodontal Diseases.Advances in experimental medicine and biology · 2022Article
- The Role ofFrontiers in cellular and infection microbiology · 2021Review
- Association betweenCurrent medical mycology · 2020Article
- Oral Candidiasis: A Disease of Opportunity.Journal of fungi (Basel, Switzerland) · 2020Review
- Pathogenetic Impact of Bacterial-Fungal Interactions.Microorganisms · 2019Review
- Candida Interactions with the Oral Bacterial Microbiota.Journal of fungi (Basel, Switzerland) · 2018Review
- Morphological and physiological changes induced by contact-dependent interaction between Candida albicans and Fusobacterium nucleatum.Scientific reports · 2016Article
- Innate Immunity and Saliva in Candida albicans-mediated Oral Diseases.Journal of dental research · 2016Review
- Real-time PCR analysis of fungal organisms and bacterial species at peri-implantitis sites.International journal of implant dentistry · 2015Article
- Cellular Components Mediating Coadherence of Candida albicans and Fusobacterium nucleatum.Journal of dental research · 2015Article
- Fap2 of Fusobacterium nucleatum is a galactose-inhibitable adhesin involved in coaggregation, cell adhesion, and preterm birth.Infection and immunity · 2015Article
- Effects of salivary protein flow and indigenous microorganisms on initial colonization of Candida albicans in an in vivo model.BMC oral health · 2012Article
- Polymicrobial interactions: impact on pathogenesis and human disease.Clinical microbiology reviews · 2012Review
- Genetic relatedness of subgingival and buccal Candida dubliniensis isolates in immunocompetent subjects assessed by RAPD-PCR.Journal of oral microbiology · 2009Article
- Cross-kingdom interactions: Candida albicans and bacteria.FEMS microbiology letters · 2009Review
- Differentiation of Candida dubliniensis from Candida albicans on rosemary extract agar and oregano extract agar.Journal of clinical laboratory analysis · 2008Article
- Detection of Candida dubliniensis in Venezuela.Mycopathologia · 2005Article
- Identification and characterization of a novel adhesin unique to oral fusobacteria.Journal of bacteriology · 2005Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The binding of microorganisms to each other and oral surfaces contributes to the progression of microbial infections in the oral cavity. Candida dubliniensis, a newly characterized species, has been identified in human immunodeficiency virus-seropositive patients and other immunocompromised individuals. C. dubliniensis phenotypically resembles Candida albicans in many respects yet can be identified and differentiated as a unique Candida species by phenotypic and genetic profiles. The purpose of this study was to determine oral coaggregation (CoAg) partners of C. dubliniensis and to compare these findings with CoAg of C. albicans under the same environmental conditions. Fifteen isolates of C. dubliniensis and 40 isolates of C. albicans were tested for their ability to coaggregate with strains of Fusobacterium nucleatum, Peptostreptococcus micros, Peptostreptococcus magnus, Peptostreptococcus anaerobius, Porphyromonas gingivalis, and Prevotella intermedia. When C. dubliniensis and C. albicans strains were grown at 37 degrees C on Sabouraud dextrose agar, only C. dubliniensis strains coaggregated with F. nucleatum ATCC 49256 and no C. albicans strains showed CoAg. However, when the C. dubliniensis and C. albicans strains were grown at 25 or 45 degrees C, both C. dubliniensis and C. albicans strains demonstrated CoAg with F. nucleatum. Heating the C. albicans strains (grown at 37 degrees C) at 85 degrees C for 30 min or treating them with dithiothreitol allowed the C. albicans strains grown at 37 degrees C to coaggregate with F. nucleatum. CoAg at all growth temperatures was inhibited by mannose and alpha-methyl mannoside but not by EDTA or arginine. The CoAg reaction between F. nucleatum and the Candida species involved a heat-labile component on F. nucleatum and a mannan-containing heat-stable receptor on the Candida species. The CoAg reactions between F. nucleatum and the Candida species may be important in the colonization of the yeast in the oral cavity, and the CoAg of C. dubliniensis by F. nucleatum when grown at 37 degrees C provides a rapid, specific, and inexpensive means to differentiate C. dubliniensis from C. albicans isolates in the clinical laboratory.
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Registered trials
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