Trial reportJournal of neurology, neurosurgery, and psychiatry1999
Isolated dysarthria due to extracerebellar lacunar stroke: a central monoparesis of the tongue.
Trial report in Journal of neurology, neurosurgery, and psychiatry, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Neuroanatomical regions associated with non-progressive dysarthria post-stroke: a systematic review.BMC neurology · 2022Pooled it
- Isolated dysarthria as the sole manifestation of myasthenia gravis: a case report.The Journal of international medical research · 2022Review
- Post-Stroke Lingual Dystonia: Clinical Description and Neuroimaging Findings.Tremor and other hyperkinetic movements (New York, N.Y.) · 2018Article
- Localization of orofacial representation in the corona radiata, internal capsule and cerebral peduncle in Macaca mulatta.The Journal of comparative neurology · 2017Article
- Myasthenia gravis mimicking stroke: a case series with sudden onset dysarthria.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015Article
- Transient hemiglossal denervation during acute internal capsule infarct in the setting of dysarthria-clumsy hand syndrome.AJNR. American journal of neuroradiology · 2010Article
- Speech disorders in right-hemisphere stroke.Neuroscience and behavioral physiology · 2010Article
- The existence of phonatory instability in multiple sclerosis: an acoustic and electroglottographic study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2010Article
- Dysarthria and paresthesia of the thumb caused by a small cortical infarction.Journal of neurology · 2007Article
- Primary face motor area as the motor representation of articulation.Journal of neurology · 2007Article
- Plasticity in corticomotor control of the human tongue musculature induced by tongue-task training.Experimental brain research · 2003Article
- Tongue Tremor in Acute Cortical Infarct.Movement disorders clinical practiceArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe pathophysiology of dysarthria can preferentially be studied in patients with the rare lacunar stroke syndrome of "isolated dysarthria".
methodsA single study was carried out on seven consecutive patients with sudden onset of isolated dysarthria due to single ischaemic lesion. The localisation of the lesion was identified using MRI. The corticolingual, cortico-orofacial, and corticospinal tract functions were investigated using transcranial magnetic stimulation. Corticopontocerebellar tract function was assessed using 99mTc hexamethylpropylene amine oxime-single photon emission computerised tomography (HMPAO-SPECT) in six patients. Sensory functions were evaluated clinically and by somatosensory evoked potentials.
resultsBrain MRI showed the lesions to be located in the corona radiata (n=4) and the internal capsule (n=2). No morphological lesion was identified in one patient. Corticolingual tract function was impaired in all patients. In four patients with additional cortico-orofacial tract dysfunction, dysarthria did not differ from that in patients with isolated corticolingual tract dysfunction. Corticospinal tract functions were normal in all patients. HMPAO-SPECT showed no cerebellar diaschisis, suggesting unimpaired corticopontocerebellar tract function. Sensory functions were not affected.
conclusionInterruption of the corticolingual pathways to the tongue is crucial in the pathogenesis of isolated dysarthria after extracerebellar lacunar stroke.
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