ArticleThe Journal of physiology1999
The Rho-related protein Rnd1 inhibits Ca2+ sensitization of rat smooth muscle.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 64 citations in OpenAlex.
- The role of the RHOA/ROCK pathway in the regulation of myometrial stages throughout pregnancy.AJOG global reports · 2024Article
- A paradoxical increase of force development in saphenous and tail arteries from heterozygous ANO1 knockout mice.Physiological reports · 2020Article
- The RND1 Small GTPase: Main Functions and Emerging Role in Oncogenesis.International journal of molecular sciences · 2019Review
- Effect of Long-Term Exercise Training on lncRNAs Expression in the Vascular Injury of Insulin Resistance.Journal of cardiovascular translational research · 2018Article
- Androgens induce nongenomic stimulation of colonic contractile activity through induction of calcium sensitization and phosphorylation of LC20 and CPI-17.Molecular endocrinology (Baltimore, Md.) · 2010Article
- UTP controls cell surface distribution and vasomotor activity of the human P2Y2 receptor through an epidermal growth factor receptor-transregulated mechanism.The Journal of biological chemistry · 2010Article
- RhoA/Rho-kinase: pathophysiologic and therapeutic implications in gastrointestinal smooth muscle tone and relaxation.Gastroenterology · 2010Review
- Involvement of Rho kinase and protein kinase C in carbachol-induced calcium sensitization in beta-escin skinned rat and guinea-pig bladders.British journal of pharmacology · 2006Article
- Mechanisms involved in carbachol-induced Ca(2+) sensitization of contractile elements in rat proximal and distal colon.British journal of pharmacology · 2004Article
- A role of Rnd1 GTPase in dendritic spine formation in hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Modulation of RhoA-Rho kinase-mediated Ca2+ sensitization of rabbit myometrium during pregnancy - role of Rnd3.The Journal of physiology · 2003Article
- The role of RhoA and Rho-associated kinase in vascular smooth muscle contraction.Current hypertension reports · 2003Review
- Role of Rho kinase signalling in healthy and varicose human saphenous veins.British journal of pharmacology · 2002Article
- Changes in the mechanisms involved in uterine contractions during pregnancy in guinea-pigs.The Journal of physiology · 2000Article
- Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II.The Journal of physiology · 2000Review
- Kinases, myosin phosphatase and Rho proteins: curiouser and curiouser.The Journal of physiology · 1999Article
- The Rho-related protein Rnd1 inhibits Ca2+ sensitization of rat smooth muscle.The Journal of physiology · 1999Article
- Pathophysiological functions of Rnd proteins.Small GTPasesReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The small GTP-binding Rho proteins are involved in the agonist-induced Ca2+ sensitization of smooth muscle. The action and the expression of Rnd1, a new member of the Rho protein family constitutively bound to GTP, has been studied in rat smooth muscle. 2. Recombinant prenylated Rnd1 (0.01-0.1 mg ml-1) dose dependently inhibited carbachol- and GTPgammaS-induced Ca2+ sensitization in beta-escin-permeabilized ileal smooth muscle strips but had no effect on the tension at submaximal [Ca2+] (pCa 6.3). Rnd1 inhibited GTPgammaS-induced tension without shifting the dose-response curves to GTPgammaS. 3. pCa-tension relationships were not modified by Rnd1 and the rise in tension induced through the inhibition of myosin light chain phosphatase by calyculin A was not affected by Rnd1. 4. The Ca2+ sensitization induced by recombinant RhoA was completely abolished when RhoA and Rnd1 were applied together. 5. Rnd1 was expressed at a low level in membrane fractions prepared from intestinal or arterial smooth muscles. The expression of Rnd1 was strongly increased in ileal and aortic smooth muscle from rats treated with progesterone or oestrogen. Progesterone-treated ileal muscle strips showed a decrease in agonist-induced Ca2+ sensitization. 6. The present study shows that (i) Rnd1 inhibits agonist- and GTPgammaS-induced Ca2+ sensitization of smooth muscle by specifically interfering with a RhoA-dependent mechanism and (ii) an increase in Rnd1 expression may account, at least in part, for the steroid-induced decrease in agonist-induced Ca2+ sensitization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.