ArticleThe Journal of physiology1999
Absence of modulation of the expressed calcium channel alpha1G subunit by alpha2delta subunits.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Increase of CaBMC research notes · 2018Article
- CACHD1 is an α2δ-Like Protein That Modulates CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The α2δ Subunit and Absence Epilepsy: Beyond Calcium Channels?Current neuropharmacology · 2017Review
- Voltage-gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology.The Journal of physiology · 2016Review
- Pharmacological Inhibition of Voltage-gated Ca(2+) Channels for Chronic Pain Relief.Current neuropharmacology · 2013Article
- Molecular regions underlying the activation of low- and high-voltage activating calcium channels.European biophysics journal : EBJ · 2005Article
- Low-voltage-activated ("T-Type") calcium channels in review.Journal of bioenergetics and biomembranes · 2003Review
- Calcium channels: unanswered questions.Journal of bioenergetics and biomembranes · 2003Review
- Calcium channel alpha2delta subunits: differential expression, function, and drug binding.Journal of bioenergetics and biomembranes · 2003Review
- Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Kinetic modification of the alpha(1I) subunit-mediated T-type Ca(2+) channel by a human neuronal Ca(2+) channel gamma subunit.The Journal of physiology · 2001Article
- The amino side of the C-terminus determines fast inactivation of the T-type calcium channel alpha1G.The Journal of physiology · 2001Article
- Calcium channel functions in pain processing.Channels (Austin, Tex.)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The modulatory action of the alpha2delta subunit on various high-voltage-activated calcium channels has been demonstrated previously. However, very little is known about auxiliary subunit modulation of low-voltage-activated (LVA) calcium channels. We have examined the modulation of the alpha1G subunit corresponding to the neuronal T-type calcium channel by the ubiquitously expressed alpha2delta-1 and brain-specific alpha2delta-3 subunits. 2. The alpha1G subunit was expressed alone or in combination with either the alpha2delta-1 or alpha2delta-3 subunit in human embryonic kidney (HEK 293) cells and whole-cell barium currents were measured. The current density-voltage relationships for peak and sustained current, kinetics of current activation and inactivation, voltage dependence of current inactivation and time course of the recovery from inactivation were analysed for each type of expressed channel. No significant difference was found for any of the examined parameters. 3. These results suggest that the LVA alpha1G channel is not regulated by known auxiliary alpha2delta subunits.
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