ArticleProceedings of the National Academy of Sciences of the United States of America1999
Expression of the antiproliferative gene TIS21 at the onset of neurogenesis identifies single neuroepithelial cells that switch from proliferative to neuron-generating division.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed, 204 citations in OpenAlex.
- PC3/Tis21/BTG2 and BTG1 genes: regulators of the cell cycle and neurogenesis, as well as tumor suppressors in malignant brain tumors.Frontiers in cell and developmental biology · 2026Review
- A low-level Cdkn1c/p57EMBO reports · 2026Article
- Unequal mitochondrial segregation promotes asymmetric fates during neurogenesis.Nature communications · 2025Article
- Neurogenesis in primates versus rodents and the value of non-human primate models.National science review · 2023Review
- Pax6 limits the competence of developing cerebral cortical cells to respond to inductive intercellular signals.PLoS biology · 2022Article
- A conserved motif in human BTG1 and BTG2 proteins mediates interaction with the poly(A) binding protein PABPC1 to stimulate mRNA deadenylation.RNA biology · 2021Article
- A single-cell guide to retinal development: Cell fate decisions of multipotent retinal progenitors in scRNA-seq.Developmental biology · 2021Review
- Comprehensive characterization of migration profiles of murine cerebral cortical neurons during development using FlashTag labeling.iScience · 2021Article
- Multimerization of Zika Virus-NS5 Causes Ciliopathy and Forces Premature Neurogenesis.Cell stem cell · 2020Article
- Electrophysiological Maturation of Cerebral Organoids Correlates with Dynamic Morphological and Cellular Development.Stem cell reports · 2020Article
- A Widespread Neurogenic Potential of Neocortical Astrocytes Is Induced by Injury.Cell stem cell · 2020Article
- Origins, Development, and Compartmentation of the Granule Cells of the Cerebellum.Frontiers in neural circuits · 2020Review
- Genes and Mechanisms Involved in the Generation and Amplification of Basal Radial Glial Cells.Frontiers in cellular neuroscience · 2019Review
- Gli3 controls the onset of cortical neurogenesis by regulating the radial glial cell cycle throughDevelopment (Cambridge, England) · 2018Article
- Article
- Isolation, culture optimization and functional characterization of stem cell neurospheres from mouse neonatal olfactory bulb and epithelium.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Article
- The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Dynamic behaviour of human neuroepithelial cells in the developing forebrain.Nature communications · 2017Article
- Article
- Bradykinin promotes neuron-generating division of neural progenitor cells through ERK activation.Journal of cell science · 2016Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At the onset of mammalian neurogenesis, neuroepithelial (NE) cells switch from proliferative to neuron-generating divisions. Understanding the molecular basis of this switch requires the ability to distinguish between these two types of division. Here we show that in the mouse ventricular zone, expression of the mRNA of the antiproliferative gene TIS21 (PC3, BTG2) (i) starts at the onset of neurogenesis, (ii) is confined to a subpopulation of NE cells that increases in correlation with the progression of neurogenesis, and (iii) is not detected in newborn neurons. Expression of the TIS21 mRNA in the NE cells occurs transiently during the cell cycle, i.e., in the G1 phase. In contrast to the TIS21 mRNA, the TIS21 protein persists through the division of NE cells and is inherited by the neurons, where it remains detectable during neuronal migration and the initial phase of differentiation. Our observations indicate that the TIS21 gene is specifically expressed in those NE cells that, at their next division, will generate postmitotic neurons, but not in proliferating NE cells. Using TIS21 as a marker, we find that the switch from proliferative to neuron-generating divisions is initiated in single NE cells rather than in synchronized neighboring cells.
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