ArticleProceedings of the National Academy of Sciences of the United States of America1999
Hormone-induced secretory and nuclear translocation of calmodulin: oscillations of calmodulin concentration with the nucleus as an integrator.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 84 citations in OpenAlex.
- Targeting Plasma Membrane CaCancers · 2026Review
- Calmodulin Regulates Transient Receptor Potential TRPM3 and TRPM8-Induced Gene Transcription.International journal of molecular sciences · 2023Article
- BH3 mimetic-elicited CaCell death & disease · 2017Article
- Strain Differences in Presynaptic Function: PROTEOMICS, ULTRASTRUCTURE, AND PHYSIOLOGY OF HIPPOCAMPAL SYNAPSES IN DBA/2J AND C57Bl/6J MICE.The Journal of biological chemistry · 2015Article
- Calcium signaling in the liver.Comprehensive Physiology · 2013Review
- Neurogranin targets calmodulin and lowers the threshold for the induction of long-term potentiation.PloS one · 2012Article
- Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptors.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Using automated imaging to interrogate gonadotrophin-releasing hormone receptor trafficking and function.Molecular and cellular endocrinology · 2011Review
- Dynamic changes in cytosolic and mitochondrial ATP levels in pancreatic acinar cells.Gastroenterology · 2010Article
- Pulsatile and sustained gonadotropin-releasing hormone (GnRH) receptor signaling: does the Ca2+/NFAT signaling pathway decode GnRH pulse frequency?The Journal of biological chemistry · 2009Article
- Calmodulin in adult mammalian skeletal muscle: localization and effect on sarcoplasmic reticulum Ca2+ release.American journal of physiology. Cell physiology · 2008Article
- Free and bound intracellular calmodulin measurements in cardiac myocytes.Cell calcium · 2007Article
- The frequencies of calcium oscillations are optimized for efficient calcium-mediated activation of Ras and the ERK/MAPK cascade.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Activity-dependent and -independent nuclear fluxes of HDAC4 mediated by different kinases in adult skeletal muscle.The Journal of cell biology · 2005Article
- Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation.The Journal of cell biology · 2004Article
- Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations.The EMBO journal · 2004Article
- Dynamics and calcium sensitivity of the Ca2+/myristoyl switch protein hippocalcin in living cells.The Journal of cell biology · 2003Article
- Spatial distribution of Ca(2+) signals during repetitive depolarizing stimuli in adrenal chromaffin cells.Biophysical journal · 2003Article
- Localized Ca2+ uncaging reveals polarized distribution of Ca2+-sensitive Ca2+ release sites: mechanism of unidirectional Ca2+ waves.The Journal of cell biology · 2002Article
- Activating calcium release through inositol 1,4,5-trisphosphate receptors without inositol 1,4,5-trisphosphate.Proceedings of the National Academy of Sciences of the United States of America · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Many important enzyme activities are regulated by Ca2+-dependent interactions with calmodulin (CaM). Some of the most important targets for CaM action are in the nucleus, and Ca2+-dependent CaM translocation into this organelle has been reported. Hormone-evoked cytosolic Ca2+ signals occur physiologically as oscillations, but, so far, oscillations in CaM concentration have not been described. We loaded fluorescent-labeled CaM into pancreatic acinar cells and monitored the fluorescence in various regions by confocal microscopy. Sustained high concentrations of the hormone cholecystokinin or the neurotransmitter acetylcholine evoked a transient movement of cytosolic CaM from the basal nonnuclear area into the secretory granule region and, thereafter, a more substantial and prolonged translocation of CaM into the nucleoplasm. About 50% of the CaM that bound Ca2+ translocated. At a lower hormone concentration, evoking Ca2+ oscillations, regular spikes of increased CaM concentration were seen in the secretory granule region with mirror image spikes of decreased CaM concentration in the basal nonnuclear region. The nucleus was able to integrate the Ca2+ spike-evoked pulses of CaM translocation into a sustained elevation of the nucleoplasmic concentration of this protein.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.