ArticleMolecular biology of the cell1999
Architecture of the nuclear periphery of rat pachytene spermatocytes: distribution of nuclear envelope proteins in relation to synaptonemal complex attachment sites.
Article in Molecular biology of the cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Nuclear Lamins: A Molecular Bridge Coupling Extracellular Mechanical Cues to Intranuclear Signal Transduction and Gene Regulation.International journal of molecular sciences · 2026Review
- Telomeres, the nuclear lamina, and membrane remodeling: Orchestrating meiotic chromosome movements.The Journal of cell biology · 2025Review
- The Nuclear Lamina.Cold Spring Harbor perspectives in biology · 2022Review
- Meiotic Nuclear Architecture in Distinct Mole Vole Hybrids with Robertsonian Translocations: Chromosome Chains, Stretched Centromeres, and Distorted Recombination.International journal of molecular sciences · 2020Article
- Expression of lamin C2 in mammalian oocytes.PloS one · 2020Article
- FBXO47 regulates telomere-inner nuclear envelope integration by stabilizing TRF2 during meiosis.Nucleic acids research · 2019Article
- Diverse roles for CDK-associated activity during spermatogenesis.FEBS letters · 2019Review
- Evolutionary changes in lamin expression in the vertebrate lineage.Nucleus (Austin, Tex.) · 2017Article
- Descriptive Analysis of LAP1 Distribution and That of Associated Proteins throughout Spermatogenesis.Membranes · 2017Article
- Confocal Analysis of Nuclear Lamina Behavior during Male Meiosis and Spermatogenesis in Drosophila melanogaster.PloS one · 2016Article
- Structural and functional adaptations of the mammalian nuclear envelope to meet the meiotic requirements.Nucleus (Austin, Tex.) · 2015Review
- Pushing the (nuclear) envelope into meiosis.Genome biology · 2013Article
- The meiotic nuclear lamina regulates chromosome dynamics and promotes efficient homologous recombination in the mouse.PLoS genetics · 2013Article
- The impact of entropy on the spatial organization of synaptonemal complexes within the cell nucleus.PloS one · 2012Article
- Tetrahymena meiotic nuclear reorganization is induced by a checkpoint kinase-dependent response to DNA damage.Molecular biology of the cell · 2009Article
- Ret Finger Protein: An E3 Ubiquitin Ligase Juxtaposed to the XY Body in Meiosis.International journal of cell biology · 2009Article
- Transmembrane protein Sun2 is involved in tethering mammalian meiotic telomeres to the nuclear envelope.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Lamins A and C are present in the nuclei of early porcine embryos, with lamin A being distributed in large intranuclear foci.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2007Article
- Telomere attachment, meiotic chromosome condensation, pairing, and bouquet stage duration are modified in spermatocytes lacking axial elements.Molecular biology of the cell · 2004Article
- Mouse germ cell-less as an essential component for nuclear integrity.Molecular and cellular biology · 2003Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nucleus of spermatocytes provides during the first meiotic prophase an interesting model for investigating relationships of the nuclear envelope (NE) with components of the nuclear interior. During the pachytene stage, meiotic chromosomes are synapsed via synaptonemal complexes (SCs) and attached through both ends to the nuclear periphery. This association is dynamic because chromosomes move during the process of synapsis and desynapsis that takes place during meiotic prophase. The NE of spermatocytes possesses some peculiarities (e.g., lower stability than in somatic cells, expression of short meiosis-specific lamin isoforms called C2 and B3) that could be critically involved in this process. For better understanding of the association of chromosomes with the nuclear periphery, in the present study we have investigated the distribution of NE proteins in relation to SC attachment sites. A major outcome was the finding that lamin C2 is distributed in the form of discontinuous domains at the NE of spermatocytes and that SC attachment sites are embedded in these domains. Lamin C2 appears to form part of larger structures as suggested by cell fractionation experiments. According to these results, we propose that the C2-containing domains represent local reinforcements of the NE that are involved in the proper attachment of SCs.
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