ArticleMolecular biology of the cell1999
Overexpression of a kinase-deficient transforming growth factor-beta type II receptor in mouse mammary stroma results in increased epithelial branching.
Article in Molecular biology of the cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 123 citations in OpenAlex.
- Collective cell migration is spatiotemporally regulated during mammary epithelial bifurcation.Journal of cell science · 2023Article
- Age-related elevation of HGF is driven by the reduction of fibroblast size in a YAP/TAZ/CCN2 axis-dependent manner.Journal of dermatological science · 2021Article
- Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland.Frontiers in cell and developmental biology · 2020Review
- TGF-β Family Signaling in Ductal Differentiation and Branching Morphogenesis.Cold Spring Harbor perspectives in biology · 2018Review
- Building branched tissue structures: from single cell guidance to coordinated construction.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Expansion of stem cells counteracts age-related mammary regression in compound Timp1/Timp3 null mice.Nature cell biology · 2015Article
- Cytokine networks that mediate epithelial cell-macrophage crosstalk in the mammary gland: implications for development and cancer.Journal of mammary gland biology and neoplasia · 2014Review
- Ltbp1L is focally induced in embryonic mammary mesenchyme, demarcates the ductal luminal lineage and is upregulated during involution.Breast cancer research : BCR · 2013Article
- Targeting TGF-β signaling in cancer.Expert opinion on therapeutic targets · 2013Review
- Oncogenic transformation of mammary epithelial cells by transforming growth factor beta independent of mammary stem cell regulation.Cancer cell international · 2013Article
- Crosstalk between TGF-beta and MAPK signaling during corneal wound healing.Investigative ophthalmology & visual science · 2011Article
- Integrated morphodynamic signalling of the mammary gland.Nature reviews. Molecular cell biology · 2011Review
- Mammary branch initiation and extension are inhibited by separate pathways downstream of TGFβ in culture.Experimental cell research · 2011Article
- Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling.Developmental biology · 2011Article
- Mammary development and breast cancer: the role of stem cells.Current molecular medicine · 2011Review
- Choreographing metastasis to the tune of LTBP.Journal of mammary gland biology and neoplasia · 2011Article
- The role of activin in mammary gland development and oncogenesis.Journal of mammary gland biology and neoplasia · 2011Review
- Wnt5a as an effector of TGFβ in mammary development and cancer.Journal of mammary gland biology and neoplasia · 2011Review
- Loss of one Tgfbr2 allele in fibroblasts promotes metastasis in MMTV: polyoma middle T transgenic and transplant mouse models of mammary tumor progression.Clinical & experimental metastasis · 2011Article
- TGF-beta biology in mammary development and breast cancer.Cold Spring Harbor perspectives in biology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Members of the transforming growth factor-beta (TGF-beta) superfamily signal through heteromeric type I and type II serine/threonine kinase receptors. Transgenic mice that overexpress a dominant-negative mutation of the TGF-beta type II receptor (DNIIR) under the control of a metallothionein-derived promoter (MT-DNIIR) were used to determine the role of endogenous TGF-betas in the developing mammary gland. The expression of the dominant-negative receptor was induced with zinc and was primarily localized to the stroma underlying the ductal epithelium in the mammary glands of virgin transgenic mice from two separate mouse lines. In MT-DNIIR virgin females treated with zinc, there was an increase in lateral branching of the ductal epithelium. We tested the hypothesis that expression of the dominant-negative receptor may alter expression of genes that are expressed in the stroma and regulated by TGF-betas, potentially resulting in the increased lateral branching seen in the MT-DNIIR mammary glands. The expression of hepatocyte growth factor mRNA was increased in mammary glands from transgenic animals relative to the wild-type controls, suggesting that this factor may play a role in TGF-beta-mediated regulation of lateral branching. Loss of responsiveness to TGF-betas in the mammary stroma resulted in increased branching in mammary epithelium, suggesting that TGF-betas play an important role in the stromal-epithelial interactions required for branching morphogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.