Evidence map›Paper›PMID 10196343›Full record

ArticleJournal of virology1999

Immunization with a live, attenuated simian immunodeficiency virus vaccine leads to restriction of viral diversity in Rhesus macaques not protected from pathogenic challenge.

D L Sodora, K E Sheridan, P A Marx, R I Connor

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

D L SodoraUniversity of Texas Southwestern Medical Center, Dallas, Texas 75235, USA.
K E Sheridan
P A Marx
R I Connor
Aaron Diamond AIDS Research Center · USRockefeller University · USThe University of Texas Southwestern Medical Center · USTulane University · US

Funding

Novel VLP-Based Mucosal and Sytemic HIV VaccinesU19AI028147 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MESTECKY, JIRI F · 2003 to 2009
$15.8M
POLIOVIRUS REPLICONS FOR HIV/SIV VACCINESP01AI028147 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MORROW, CASEY D · 1998 to 2002
$5.1M
MUCOSAL SIV VACCINESR01AI036598 · NIAID · AARON DIAMOND AIDS RESEARCH CENTER · PI MARX, PRESTON A · 1994 to 1997
–
RECOMBINANT VACCINES DERIVED FROM POLIOVIRUSU01AI028147 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MORROW, CASEY D · 1989 to 1997
–
NIAID NIH HHS AI28147NIAID NIH HHS AI36598NIAID NIH HHS P01 AI028147NIAID NIH HHS U01 AI028147NIAID NIH HHS U19 AI028147
6 · The paper itself

Abstract

Rhesus macaques immunized with simian immunodeficiency virus SIVmac239Deltanef but not protected from SIVmac251 challenge were studied to determine the genetic and biological characteristics of the breakthrough viruses. Assessment of SIV genetic diversity (env V1-V2) revealed a reduction in the number of viral species in the immunized, unprotected macaques, compared to the number in nonimmunized controls. However, no evidence for selection of a specific V1-V2 genotype was observed, and biologically cloned isolates from the animals with breakthrough virus were similar with respect to replication kinetics and coreceptor use in vitro.

Indexed as

Amino Acid SequenceAnimalsCell LineGene Products, nefGenotypeHumansMacaca mulattaMolecular Sequence DataPolymerase Chain ReactionReceptors, VirusSAIDS VaccinesSequence Homology, Amino AcidSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusVaccinationVaccines, AttenuatedGene Products, nefReceptors, VirusSAIDS VaccinesVaccines, Attenuated

Identifiers

PMID10196343
PMCPMC104226
OpenAlexW1607591678

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.