ArticleJournal of virology1999
Design of 5' untranslated sequences in retroviral vectors developed for medical use.
Article in Journal of virology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
67 citing papers in PubMed.
- Biparatopic targeting of CD38 using CD38-specific trimeric antibody recruiters improves cytotoxicity against multiple myeloma.Frontiers in immunology · 2026Article
- Targeted gene delivery systems for T-cell engineering.Cellular oncology (Dordrecht, Netherlands) · 2024Review
- The neuronal transcription factor MEIS2 is a calpain-2 protease target.Journal of cell science · 2024Article
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- TGFCells · 2023Article
- Retroviral gene therapy in Germany with a view on previous experience and future perspectives.Gene therapy · 2021Review
- TEG001 Insert Integrity from Vector Producer Cells until Medicinal Product.Molecular therapy : the journal of the American Society of Gene Therapy · 2020Article
- Nanobody-based CD38-specific heavy chain antibodies induce killing of multiple myeloma and other hematological malignancies.Theranostics · 2020Article
- Lentiviral Vectors with Cellular Promoters Correct Anemia and Lethal Bone Marrow Failure in a Mouse Model for Diamond-Blackfan Anemia.Molecular therapy : the journal of the American Society of Gene Therapy · 2017Article
- Clonal competition in BcrAbl-driven leukemia: how transplantations can accelerate clonal conversion.Molecular cancer · 2017Article
- Pbx1 is required for adult subventricular zone neurogenesis.Development (Cambridge, England) · 2016Article
- Article
- Phosphorylation of murine SAMHD1 regulates its antiretroviral activity.Retrovirology · 2015Article
- Tetraspanin CD9 determines invasiveness and tumorigenicity of human breast cancer cells.Oncotarget · 2015Article
- Influenza virus-specific TCR-transduced T cells as a model for adoptive immunotherapy.Human vaccines & immunotherapeutics · 2013Article
- Spontaneous formation of tumorigenic hybrids between breast cancer and multipotent stromal cells is a source of tumor heterogeneity.The American journal of pathology · 2012Article
- Scale-up and manufacturing of clinical-grade self-inactivating γ-retroviral vectors by transient transfection.Gene therapy · 2012Article
- Fetal liver-derived mesenchymal stem cell engraftment after allogeneic in utero transplantation into rabbits.Stem cells and development · 2012Article
- The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cells.PLoS pathogens · 2011Article
- Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery.Nucleic acids research · 2011Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Utilizing genetic modules of simple retroviruses, we have developed a novel generation of gene transfer vectors with improved therapeutic potential. In the 5' untranslated "leader" sequences, all AUG codons which may aberrantly initiate translation and all viral coding sequences were removed. Thus, the probability of expressing unwanted peptides and the potential for homologous recombination with retroviral genes were largely reduced, and the cloning capacity was increased. The transgene was inserted to replace the viral gag sequences, and a new minimal splice acceptor was introduced, resulting in increased expression with all genes tested (those coding for human multidrug resistance 1 and enhanced green fluorescent protein, as well as the lacZ gene). These vectors may represent attractive tools for human gene therapy, because they increase the efficiency of transgene expression and may also increase safety in medical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.