ArticleJournal of virology1999
Frequent detection of escape from cytotoxic T-lymphocyte recognition in perinatal human immunodeficiency virus (HIV) type 1 transmission: the ariel project for the prevention of transmission of HIV from mother to infant.
Article in Journal of virology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 72 citations in OpenAlex.
- No Difference in the Prevalence of HIV-1Vaccines · 2023Article
- Understanding Viral and Immune Interplay During Vertical Transmission of HIV: Implications for Cure.Frontiers in immunology · 2021Review
- Impact of a single HLA-A*24:02-associated escape mutation on the detrimental effect of HLA-B*35:01 in HIV-1 control.EBioMedicine · 2018Article
- The role of MHC class I allele Mamu-A*07 during SIV(mac)239 infection.Immunogenetics · 2011Article
- Molecular mechanisms of HIV-1 mother-to-child transmission and infection in neonatal target cells.Life sciences · 2011Review
- Fetal allostimulation of maternal cells: a potential mechanism for perinatal HIV transmission following obstetrical hemorrhage.AIDS research and human retroviruses · 2008Article
- Article
- Characterization of HIV-1 envelope gp41 genetic diversity and functional domains following perinatal transmission.Retrovirology · 2006Article
- Molecular characterization of the HIV-1 gag nucleocapsid gene associated with vertical transmission.Retrovirology · 2006Article
- Role of viral evolutionary rate in HIV-1 disease progression in a linked cohort.Retrovirology · 2005Article
- Conservation of functional domains and limited heterogeneity of HIV-1 reverse transcriptase gene following vertical transmission.Retrovirology · 2005Article
- Molecular epidemiology of hepatitis C virus genotype 4 isolates in Egypt and analysis of the variability of envelope proteins E1 and E2 in patients with chronic hepatitis.Journal of clinical microbiology · 2005Article
- Mapping sites of positive selection and amino acid diversification in the HIV genome: an alternative approach to vaccine design?Genetics · 2004Article
- Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection.Journal of virology · 2004Article
- Influence of random genetic drift on human immunodeficiency virus type 1 env evolution during chronic infection.Genetics · 2004Article
- The role of infant immune responses and genetic factors in preventing HIV-1 acquisition and disease progression.Clinical and experimental immunology · 2003Review
- Identification of sequential viral escape mutants associated with altered T-cell responses in a human immunodeficiency virus type 1-infected individual.Journal of virology · 2003Article
- Clustering patterns of cytotoxic T-lymphocyte epitopes in human immunodeficiency virus type 1 (HIV-1) proteins reveal imprints of immune evasion on HIV-1 global variation.Journal of virology · 2002Article
- Human immunodeficiency virus-specific CD8(+) T cells in human breast milk.Journal of virology · 2002Article
- Comprehensive screening for human immunodeficiency virus type 1 subtype-specific CD8 cytotoxic T lymphocytes and definition of degenerate epitopes restricted by HLA-A0207 and -C(W)0304 alleles.Journal of virology · 2002Article
Corrections and comments
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Authors and funding
16 authors at 10 institutions in 1 country.
Funding
Abstract
Host immunologic factors, including human immunodeficiency virus (HIV)-specific cytotoxic T lymphocytes (CTL), are thought to contribute to the control of HIV type 1 (HIV-1) replication and thus delay disease progression in infected individuals. Host immunologic factors are also likely to influence perinatal transmission of HIV-1 from infected mother to infant. In this study, the potential role of CTL in modulating HIV-1 transmission from mother to infant was examined in 11 HIV-1-infected mothers, 3 of whom transmitted virus to their offspring. Frequencies of HIV-1-specific human leukocyte antigen class I-restricted CTL responses and viral epitope amino acid sequence variation were determined in the mothers and their infected infants. Maternal HIV-1-specific CTL clones were derived from each of the HIV-1-infected pregnant women. Amino acid substitutions within the targeted CTL epitopes were more frequently identified in transmitting mothers than in nontransmitting mothers, and immune escape from CTL recognition was detected in all three transmitting mothers but in only one of eight nontransmitting mothers. The majority of viral sequences obtained from the HIV-1-infected infant blood samples were susceptible to maternal CTL. These findings demonstrate that epitope amino acid sequence variation and escape from CTL recognition occur more frequently in mothers that transmit HIV-1 to their infants than in those who do not. However, the transmitted virus can be a CTL susceptible form, suggesting inadequate in vivo immune control.
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