ArticleJournal of virology1999
Host-specific modulation of the selective constraints driving human immunodeficiency virus type 1 env gene evolution.
Article in Journal of virology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Phylogenetics in HIV transmission: taking within-host diversity into account.Current opinion in HIV and AIDS · 2019Review
- The CpG dinucleotide content of the HIV-1 envelope gene may predict disease progression.Scientific reports · 2017Article
- Highly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllers.Retrovirology · 2017Article
- HIV Progression Depends on Codon and Amino Acid Usage Profile of Envelope Protein and Associated Host-Genetic Influence.Frontiers in microbiology · 2017Article
- Similarities between Human Immunodeficiency Virus Type 1 and Hepatitis C Virus Genetic and Phenotypic Protease Quasispecies Diversity.Journal of virology · 2015Article
- Molecular evolution of HIV-1 CRF01_AE Env in Thai patients.PloS one · 2011Article
- HIV-1 subtype C envelope characteristics associated with divergent rates of chronic disease progression.Retrovirology · 2010Article
- Evolution and recombination of genes encoding HIV-1 drug resistance and tropism during antiretroviral therapy.Virology · 2010Article
- Genetic and phylogenetic evolution of HIV-1 in a low subtype heterogeneity epidemic: the Italian example.Retrovirology · 2007Review
- Sequential turnover of human immunodeficiency virus type 1 env throughout the course of infection.Journal of virology · 2006Article
- Low human immunodeficiency virus envelope diversity correlates with low in vitro replication capacity and predicts spontaneous control of plasma viremia after treatment interruptions.Journal of virology · 2005Article
- Intrapatient diversity and its correlation with viral setpoint in human immunodeficiency virus type 1 CRF02_A/G-IbNG infection.Journal of virology · 2002Article
- Selection for human immunodeficiency virus type 1 recombinants in a patient with rapid progression to AIDS.Journal of virology · 2002Article
- Reevaluation of amino acid variability of the human immunodeficiency virus type 1 gp120 envelope glycoprotein and prediction of new discontinuous epitopes.Journal of virology · 2000Article
- Consistent viral evolutionary changes associated with the progression of human immunodeficiency virus type 1 infection.Journal of virology · 1999Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To address the evolution of human immunodeficiency virus type 1 (HIV-1) within a single host, we analyzed the HIV-1 C2-V5 env regions of both cell-free genomic-RNA- and proviral-DNA-derived clones. Sequential samples were collected over a period of 3 years from six untreated subjects (three typical progressors [TPs] and three slow progressors [SPs], all with a comparable length of infection except one. The evolutionary analysis of the C2-V5 env sequences performed on 506 molecular clones (253 RNA- and 253 DNA-derived sequences) highlighted a series of differences between TPs and SPs. In particular, (i) clonal sequences from SPs (DNA and RNA) showed lower nucleotide similarity than those from TPs (P = 0. 0001), (ii) DNA clones from SPs showed higher intra- and intersample nucleotide divergence than those from TPs (P < 0.05), (iii) higher host-selective pressure was generally detectable in SPs (DNA and RNA sequences), and (iv) the increase in the genetic distance of DNA and RNA sequences over time was paralleled by an increase in both synonymous (Ks) and nonsynonymous (Ka) substitutions in TPs but only in nonsynonymous substitutions in SPs. Several individual peculiarities of the HIV-1 evolutionary dynamics emerged when the V3, V4, and V5 env regions of both TPs and SPs were evaluated separately. These peculiarities, probably reflecting host-specific features of selective constraints and their continuous modulation, are documented by the dynamics of Ka/Ks ratios of hypervariable env domains.
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