ArticleNature neuroscience1999
Learning enhances adult neurogenesis in the hippocampal formation.
Article in Nature neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 618 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
618 citing papers in PubMed.
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- High-intensity training enhances executive function in children in a randomized, placebo-controlled trial.eLife · 2017Trial
- The Dentate Gyrus Grows Throughout Life Despite Turnover of Developmentally-Born Neurons.Hippocampus · 2026Article
- Hydroxytyrosol Mitigates Anxiety-Like Behaviors After a Traumatic Experience in Aged Mice in Parallel With Increased Neurogenesis in the Ventral and Dorsal Dentate Gyrus, and Preservation of Gut Microbiota Composition.Journal of neurochemistry · 2026Article
- Ameliorative Effects of Urolithin A Against Cadmium-Induced NLRP3-Mediated Pyroptosis and Cognitive Deficits Via Regulating Aryl Hydrocarbon Receptor Signaling.Biological trace element research · 2026Article
- Proton versus photon radiotherapy in adults with primary brain tumors evaluating functional survival: a phase 3 randomized controlled trial study protocol (PRIDE).Radiation oncology (London, England) · 2026Article
- Paternal Deprivation Alters Neural Stem Cells Proliferation and Epigenetic Histone Modifications in the Neurogenic Niches of Adult Prairie Voles.International journal of molecular sciences · 2026Article
- Invariant HVC size in female canaries singing under testosterone: Unlocking function through neural differentiation, not growth.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Resolving the design principles that control post-natal vascular growth and scaling.Cell systems · 2025Article
- Ouabain increases neuronal differentiation of hippocampal neural precursor cells.Current research in neurobiology · 2025Article
- Effects of Testosterone and Its Major Metabolites upon Different Stages of Neuron Survival in the Dentate Gyrus of Male Rats.Biomolecules · 2025Article
- Therapeutic potential of stem cell-derived extracellular vesicles in neurodegenerative diseases associated with cognitive decline.Stem cells (Dayton, Ohio) · 2025Review
- Mechanism of Action and Therapeutic Potential of Xanthohumol in Prevention of Selected Neurodegenerative Diseases.Molecules (Basel, Switzerland) · 2025Review
- Cellular and synaptic organization of the Octopus vertical lobe.bioRxiv : the preprint server for biology · 2025Article
- Exploring the mechanisms influencing psychological adaptation in athletes in high-risk sports: a moderated mediation model.Scientific reports · 2025Article
- Hippocampal Neurogenesis via Light-Intensity Running and Its Mechanism.Advances in neurobiology · 2025Review
- EphB2 activation in neural stem cells in the basolateral amygdala facilitates neurogenesis and enhances long-term memory.Cellular and molecular life sciences : CMLS · 2024Article
- Chronic chemogenetic activation of hippocampal progenitors enhances adult neurogenesis and modulates anxiety-like behavior and fear extinction learning.IBRO neuroscience reports · 2024Article
- Aging Modulates the Ability of Quiescent Radial Glia-Like Stem Cells in the Hippocampal Dentate Gyrus to be Recruited into Division by Pro-neurogenic Stimuli.Molecular neurobiology · 2024Article
- Conditioned morphine tolerance promotes neurogenesis, dendritic remodelling and pro-plasticity molecules in the adult rat hippocampus.Addiction biology · 2024Article
558 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Thousands of hippocampal neurons are born in adulthood, suggesting that new cells could be important for hippocampal function. To determine whether hippocampus-dependent learning affects adult-generated neurons, we examined the fate of new cells labeled with the thymidine analog bromodeoxyuridine following specific behavioral tasks. Here we report that the number of adult-generated neurons doubles in the rat dentate gyrus in response to training on associative learning tasks that require the hippocampus. In contrast, training on associative learning tasks that do not require the hippocampus did not alter the number of new cells. These findings indicate that adult-generated hippocampal neurons are specifically affected by, and potentially involved in, associative memory formation.
Indexed as
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10195219What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.