ArticleArchives of disease in childhood. Fetal and neonatal edition1998
Trisomy 21 associated transient neonatal myeloproliferation in the absence of Down's syndrome.
Article in Archives of disease in childhood. Fetal and neonatal edition, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Clinical characterization and genetic analysis of transient abnormal myelopoiesis without the down syndrome phenotype.Molecular genetics and metabolism reports · 2025Article
- miR-1202 acts as anti-oncomiR in myeloid leukaemia by down-modulating GATA-1Open biology · 2024Article
- Transient Abnormal Myelopoeisis and Mosaic Down Syndrome in a Phenotypically Normal Newborn.Children (Basel, Switzerland) · 2020Article
- Transient leukemia in a newborn without Down syndrome: case report and review of the literature.European journal of pediatrics · 2014Review
- Transient myeloproliferative disorder and GATA1 mutation in neonates with and without Down syndrome.Indian journal of pediatrics · 2011Article
- Transient abnormal myelopoiesis in a cytogenetically normal neonate.International journal of hematology · 2010Article
- Haematology of Down syndrome.Archives of disease in childhood. Fetal and neonatal edition · 2007Review
- Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although usually associated with Down's syndrome, transient neonatal myeloproliferation (TMD) can occur in the absence of a constitutional trisomy 21. This report describes two such cases, both of whom had a trisomy 21 restricted to clonal cells. Unlike in previous such reported cases, spontaneous morphological, cytogenetic, and molecular remission in both cases was followed by re-emergence, in one case, of an evolved clone with a more malignant phenotype which required pharmacological intervention. Awareness that trisomy 21 bearing leukaemia in the neonatal period can be transient even in the absence of Down's syndrome is important to prevent unnecessary treatment. Equally, such cases require indefinite follow up as a proportion may have a recurrence which may require treatment.
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Registered trials
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