ArticleArchives of disease in childhood. Fetal and neonatal edition1998
Predictive value of plasma and cerebrospinal fluid tumour necrosis factor-alpha and interleukin-1 beta concentrations on outcome of full term infants with hypoxic-ischaemic encephalopathy.
Article in Archives of disease in childhood. Fetal and neonatal edition, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Neonatal Encephalopathy biomarkers: outcome prediction from blood samples: systematic review and meta-analysis.Pediatric research · 2026Pooled it
- The association of cord serum cytokines with neurodevelopmental outcomes.American journal of perinatology · 2015Trial
- Inflammation mediated brain damage and cytokine expression in a maternally derived murine model for preterm hypoxic-ischemic encephalopathy.Frontiers in systems biology · 2025Article
- Chronic Inflammation Offers Hints About Viable Therapeutic Targets for Preeclampsia and Potentially Related Offspring Sequelae.International journal of molecular sciences · 2024Review
- Brain temperature monitoring in newborn infants: Current methodologies and prospects.Frontiers in pediatrics · 2022Review
- Interleukins in diagnosis of perinatal asphyxia: A systematic review.International journal of reproductive biomedicine · 2019Article
- The impact of hypoxic-ischemic brain injury on stem cell mobilization, migration, adhesion, and proliferation.Neural regeneration research · 2018Review
- Systemic infusions of anti-interleukin-1β neutralizing antibodies reduce short-term brain injury after cerebral ischemia in the ovine fetus.Brain, behavior, and immunity · 2018Article
- Distinct cytokine patterns may regulate the severity of neonatal asphyxia-an observational study.Journal of neuroinflammation · 2017Observational
- A comparison of blood and cerebrospinal fluid cytokines (IL-1β, IL-6, IL-18, TNF-α) in neonates with perinatal hypoxia.Bosnian journal of basic medical sciences · 2017Article
- Systemic pro-inflammatory cytokine status following therapeutic hypothermia in a piglet hypoxia-ischemia model.Journal of neuroinflammation · 2017Article
- Hypoxic-ischemic brain damage induces distant inflammatory lung injury in newborn piglets.Pediatric research · 2016Article
- Pathophysiology and neuroprotection of global and focal perinatal brain injury: lessons from animal models.Pediatric neurology · 2015Review
- Inflammatory mediators as predictors of outcome in perinatal asphyxia.Indian journal of pediatrics · 2015Article
- Sexually dimorphic outcomes and inflammatory responses in hypoxic-ischemic encephalopathy.Journal of neuroinflammation · 2015Article
- Clinical significance of interleukin-6, tumor necrosis factor-α and high-sensitivity C-reactive protein in neonates with hypoxic-ischemic encephalopathy.Experimental and therapeutic medicine · 2014Article
- Role of immunoglobulin in neuronal apoptosis in a neonatal rat model of hypoxic ischemic brain injury.Experimental and therapeutic medicine · 2014Article
- Long-term disorders of behavior in rats induced by administration of tumor necrosis factor during early postnatal ontogenesis.Neuroscience and behavioral physiology · 2009Article
- Cytokines and perinatal brain damage.Clinics in perinatology · 2008Review
- Elevated inflammatory markers in a group of amyotrophic lateral sclerosis patients from northern India.Neurochemical research · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine the predictive value of plasma and cerebrospinal fluid (CSF) tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) concentrations on the outcome of hypoxic-ischaemic encephalopathy (HIE) in full term infants.
methodsThirty term infants with HIE were included in the study. HIE was classified according to the criteria of Sarnat and Sarnat. Blood and CSF were obtained within the first 24 hours of life and stored until assay. Five infants died soon after hypoxic insult. Neurological examinations and Denver Developmental Screening Test (DDST) were performed at 12 months in the survivors.
resultsAt the age of 12 months neurological examination and DDST showed that 11 infants were normal; 14 had abnormal neurological findings and/or an abnormal DDST result. Eleven normal infants were classified as group 1 and 19 infants (14 with abnormal neurological findings and/or an abnormal DDST and five who died) as group 2. CSF IL-1 beta and TNF-alpha concentrations in group 2 were significantly higher than those in group 1. Plasma IL-1 beta and TNF-alpha concentrations were not significantly different between the two groups. IL-1 beta, but not TNF-alpha concentrations, in group 2 were even higher than those in group 1, although non-survivors were excluded from group 2. When the patients were evaluated according to the stages of Sarnat, the difference in the three groups was again significant. Patients whose CSF samples were taken within 6 hours of the hypoxic insult had higher IL-1 beta and TNF-alpha concentrations than the patients whose samples were taken after 6 hours.
conclusionsBoth cytokines probably contribute to the damage sustained by the central nervous system after hypoxic insult. IL-1 beta seems to be a better predictor of HIE than TNF-alpha.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.