ReviewMedizinische Klinik (Munich, Germany : 1983)1999
["Targeted delivery" in the gastrointestinal tract].
Review in Medizinische Klinik (Munich, Germany : 1983), 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug delivery to the intestine has become attractive to researchers with the main interest in the delivery of peptide drugs to the large intestine and the treatment of colonic diseases. There are currently 4 strategies that are pursued to reach colon specificity: 1. by relying on the pH difference between the small and the large intestine; 2. by exploiting the enzymatic activity of the colonic microflora; 3. by relying on the relatively constant small intestinal transit time and 4. by taking advantage of the increase of the luminal pressure in the colon due to strong peristaltic waves. Drug delivery to the small intestine may be achieved by pH-controlled and time-controlled drug release mechanisms. Diffusion-controlled systems allow drug delivery over the entire gastrointestinal tract.
Indexed as
Identifiers
10194941What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.