ArticleThe Journal of clinical investigation1999
Angiotensin II attenuates renal cortical cyclooxygenase-2 expression.
Article in The Journal of clinical investigation, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 199 citations in OpenAlex.
- Kidney Angiotensin in Cardiovascular Disease: Formation and Drug Targeting.Pharmacological reviews · 2022Review
- Myeloid cyclooxygenase-2/prostaglandin E2/E-type prostanoid receptor 4 promotes transcription factor MafB-dependent inflammatory resolution in acute kidney injury.Kidney international · 2022Article
- Potential role of estradiol in ovariectomy-induced derangement of renal endocrine functions.Renal failure · 2019Article
- Cyclo-Oxygenase (COX) Inhibitors and Cardiovascular Risk: Are Non-Steroidal Anti-Inflammatory Drugs Really Anti-Inflammatory?International journal of molecular sciences · 2019Review
- Differential compensation of two cyclooxygenases in renal homeostasis is independent of prostaglandin-synthetic capacity under basal conditions.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Article
- Interaction of the renin angiotensin and cox systems in the kidney.Frontiers in bioscience (Scholar edition) · 2016Review
- Down-regulation of cyclooxygenase-2 by the carboxyl tail of the angiotensin II type 1 receptor.The Journal of biological chemistry · 2014Article
- Tubular control of renin synthesis and secretion.Pflugers Archiv : European journal of physiology · 2013Review
- Physiologic and pathophysiologic roles of cyclooxygenase-2 in the kidney.Transactions of the American Clinical and Climatological Association · 2013Article
- Tumor necrosis factor-alpha induces renal cyclooxygenase-2 expression in response to hypercalcemia.Prostaglandins & other lipid mediators · 2012Article
- Eicosanoids and tumor necrosis factor-alpha in the kidney.Prostaglandins & other lipid mediators · 2012Review
- Prostaglandin E2 EP3 receptor regulates cyclooxygenase-2 expression in the kidney.American journal of physiology. Renal physiology · 2012Article
- Prostaglandin EP1 receptor down-regulates expression of cyclooxygenase-2 by facilitating its proteasomal degradation.The Journal of biological chemistry · 2012Article
- Synthesis and secretion of renin in mice with induced genetic mutations.Kidney international · 2012Review
- Convergence of major physiological stimuli for renin release on the Gs-alpha/cyclic adenosine monophosphate signaling pathway.Clinical and experimental nephrology · 2012Review
- A major role for the EP4 receptor in regulation of renin.American journal of physiology. Renal physiology · 2011Article
- Intrarenal dopamine deficiency leads to hypertension and decreased longevity in mice.The Journal of clinical investigation · 2011Article
- Nonsteroidal Anti-Inflammatory Drugs and the Kidney.Pharmaceuticals (Basel, Switzerland) · 2010Review
- Macula densa sensing and signaling mechanisms of renin release.Journal of the American Society of Nephrology : JASN · 2010Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
We have previously shown that in rat renal cortex, cyclooxygenase-2 (COX-2) expression is localized to cTALH cells in the region of the macula densa, and that dietary salt restriction increases COX-2 expression. Administration of the angiotensin converting inhibitor, captopril, further increased COX-2 mRNA and renal cortical COX-2 immunoreactivity, with the most pronounced expression in the macula densa. Administration of an AT1 receptor antagonist, losartan, also significantly increased cortical COX-2 mRNA expression and COX-2 immunoreactivity. Mutant mice homozygous for both Agtr1a and Agtr1b null mutations (Agtr1a-/-,Agtr1b-/-) demonstrated large increases in immunoreactive COX-2 expression inthe cTALH/macula densa. To determine whether increased COX-2expression in response to ACE inhibition mediated increases in renin production, rats were treated with captopril for one week with or without the specific COX-2 inhibitor, SC58236. Plasma renin activity increased significantly in the captropril group, and this increase was significantly inhibited by simultaneous treatment with SC58236. Thus, these studies indicated that angiotensin II inhibitors augment upregulation of renal cortical COX-2 in states of volume depletion, suggesting that negative feedback by the renin-angiotensin system modulates renal cortical COX-2 expression and that COX-2 is a mediator of increased renin production in response to inhibition of angiotension II production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.