Evidence map›Paper›PMID 10194465›Full record

ReviewThe Journal of clinical investigation1999

Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance.

A Virkamäki, K Ueki, C R Kahn

Abstract readReview
In one paragraph

Review in The Journal of clinical investigation, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 180 papers.

0numbers the graph read from it
0cells of the map it votes in
180citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

180 citing papers in PubMed.

  1. Trial
  2. Insulin resistance with aging: effects of diet and exercise.Sports medicine (Auckland, N.Z.) · 2000
    Trial
  3. Review
  4. Review
  5. Article
  6. Aptamers in Drug Delivery Development.Materials today (Kidlington, England) · 2025
    Article
  7. Article
  8. Article
  9. mCell metabolism · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Endothelial Dysfunction in Obesity and Therapeutic Targets.Advances in experimental medicine and biology · 2024
    Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Computational and structural biotechnology journal · 2023
    Article
  20. Article

120 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

A VirkamäkiResearch Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
K Ueki
C R Kahn

Funding

INSULIN RECEPTOR STRUCTURE AND TURNOVERR37DK031036 · NIDDK · JOSLIN DIABETES CENTER · PI KAHN, C RONALD · 2000 to 2019
$12.9M
Insulin Receptor Substrates and Insulin ActionR01DK033201 · NIDDK · JOSLIN DIABETES CENTER · PI KAHN, C RONALD · 1986 to 2016
$10.6M
The Insulin Receptor and Its Signaling MechanismsR01DK031036 · NIDDK · JOSLIN DIABETES CENTER · PI C RONALD KAHN · 1986 to 2026
$4.2M
GENE EXPRESSION IN DIABETES BY SUBTRACTIVE CLONINGR01DK045935 · NIDDK · JOSLIN DIABETES CENTER · PI KAHN, C RONALD · 1993 to 2003
$2.8M
NIDDK NIH HHS DK-31036NIDDK NIH HHS DK-33201NIDDK NIH HHS DK-45935NIDDK NIH HHS R01 DK031036NIDDK NIH HHS R01 DK033201NIDDK NIH HHS R01 DK045935NIDDK NIH HHS R37 DK031036
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Insulin ResistanceSignal TransductionAnimalsGene TargetingHumansInsulinPhosphatidylinositol 3-KinasesPhosphorylationProtein BindingReceptor, Insulinsrc Homology DomainsInsulinPhosphatidylinositol 3-KinasesReceptor, Insulin

Identifiers

PMID10194465
PMCPMC408269

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.