ReviewMolecular pathology : MP1998
Genetic risk factors in Alzheimer's disease.
Review in Molecular pathology : MP, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 73 citations in OpenAlex.
- Microbial links to Alzheimer's disease.PLoS pathogens · 2025Review
- Analysis of the Correlation BetweenPathogens (Basel, Switzerland) · 2024Article
- Protein Oxidation in Aging and Alzheimer's Disease Brain.Antioxidants (Basel, Switzerland) · 2024Review
- Phenome-Wide Association Study of Polygenic Risk Score for Alzheimer's Disease in Electronic Health Records.Frontiers in aging neuroscience · 2022Article
- Multi-pathogen infections and Alzheimer's disease.Microbial cell factories · 2021Review
- Central and Peripheral Metabolic Defects Contribute to the Pathogenesis of Alzheimer's Disease: Targeting Mitochondria for Diagnosis and Prevention.Antioxidants & redox signaling · 2020Review
- Longer TOMM40 poly-T variants associated with higher FDDNP-PET medial temporal tau and amyloid binding.PloS one · 2018Article
- mtDNA Mutations and Their Role in Aging, Diseases and Forensic Sciences.Aging and disease · 2013Review
- Biology of mitochondria in neurodegenerative diseases.Progress in molecular biology and translational science · 2012Review
- Expression of ErbB4 in the neurons of Alzheimer's disease brain and APP/PS1 mice, a model of Alzheimer's disease.Anatomy & cell biology · 2011Article
- Postgenomics, uncertain futures, and the familiarization of susceptibility genes.Social science & medicine (1982) · 2011Article
- "Forward genetics" as a method to maximize power and cost-efficiency in studies of human complex traits.Behavior genetics · 2010Article
- Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases.Pharmaceuticals (Basel, Switzerland) · 2010Article
- Limited clearance of pre-existing amyloid plaques after intracerebral injection of Abeta antibodies in two mouse models of Alzheimer disease.Journal of neuropathology and experimental neurology · 2008Article
- Large-scale studies of the functional K variant of the butyrylcholinesterase gene in relation to Type 2 diabetes and insulin secretion.Diabetologia · 2004Article
- Normal tension glaucoma is not associated with the common apolipoprotein E gene polymorphisms.The British journal of ophthalmology · 2004Article
- The role of insulin resistance in the pathogenesis of Alzheimer's disease: implications for treatment.CNS drugs · 2003Review
- Closing in on the amyloid cascade: recent insights into the cell biology of Alzheimer's disease.Molecular neurobiologyReview
- More than just a number: the gut microbiota and brain function across the extremes of life.Gut microbesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Following a brief introduction and discussion of the pathological features of Alzheimer's disease, the main emphasis of this review article will be the genetic factors that have been implicated in this disease. These can be divided into two main categories. First, the three genes in which mutations are known to result in early onset autosomal dominant familial Alzheimer's disease will be discussed. These are well characterised but account for only a small proportion of Alzheimer's disease cases. Late onset, sporadic Alzheimer's disease is more common and evidence suggests that there is a genetic component to this type of disease. A number of genetic risk factors have been implicated that might increase the risk of developing sporadic disease. Many of these are controversial and studies have shown conflicting results, which are discussed in this section. Finally, a brief discussion of some of the mechanisms suggested to play a role in the pathogenesis of Alzheimer's disease is included. It is hoped that this will show why particular genes have been implicated in Alzheimer's disease and how they might be able to influence the development of the disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.