ArticleClinical and experimental immunology1999
Enhanced expression of L-selectin on peripheral blood lymphocytes from patients with IgA nephropathy.
Article in Clinical and experimental immunology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- GALNT14 deficiency: connecting multiple links in the IgA nephropathy pathogenetic chain.The Journal of clinical investigation · 2025Article
- Loss of GalNAc-T14 links O-glycosylation defects to alterations in B cell homing in IgA nephropathy.The Journal of clinical investigation · 2025Article
- Present and Future of IgA Nephropathy and Membranous Nephropathy Immune Monitoring: Insights from Molecular Studies.International journal of molecular sciences · 2023Review
- New Insights into the Treatment of Glomerular Diseases: When Mechanisms Become Vivid.International journal of molecular sciences · 2022Review
- The Role of Immune Modulation in Pathogenesis of IgA Nephropathy.Frontiers in medicine · 2020Review
- Monitoring Immune Responses in IgA Nephropathy: Biomarkers to Guide Management.Frontiers in immunology · 2020Review
- A New Vision of IgA Nephropathy: The Missing Link.International journal of molecular sciences · 2019Review
- Assay for galactose-deficient IgA1 enables mechanistic studies with primary cells from IgA nephropathy patients.BioTechniques · 2018Article
- New insights into the pathogenesis of IgA nephropathy.Pediatric nephrology (Berlin, Germany) · 2018Review
- The Origin and Activities of IgA1-Containing Immune Complexes in IgA Nephropathy.Frontiers in immunology · 2016Review
- Immunopathogenesis of IgAN.Seminars in immunopathology · 2007Review
- Functional impact of IgA nephropathy-associated selectin gene haplotype on leukocyte-endothelial interaction.Immunogenetics · 2006Article
- Role of selectins in glomerulonephritis.Clinical and experimental immunology · 2002Review
- Association between single-nucleotide polymorphisms in selectin genes and immunoglobulin A nephropathy.American journal of human genetics · 2002Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the homing characteristics of T and B lymphocytes which could explain the abnormal partition of IgA-producing cells in tonsils and bone marrow from patients with IgA nephropathy (IgAN), the expression of leucocyte adhesion molecules (CD11a, CD29, CD49d, CD62L, CD31) was assessed using flow cytometry on peripheral blood leucocytes from patients with biopsy-proven IgAN and controls. Higher proportions of T and B lymphocytes expressing higher amounts of L-selectin, as well as higher proportions of B cells expressing more CD31 were evidenced in IgAN patients. Conversely, serum levels of sCD62L were not different from controls, but significantly higher than serum levels in patients suffering from other renal diseases. We hypothesize that this over-expression of CD62L and CD31 may be involved in an enhanced efficiency of lymphoid cells homing to lymphoid tissues in this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.