Evidence map›Paper›PMID 10193389›Full record

ArticleThorax1998

Early childhood infection and atopic disorder.

I S Farooqi, J M Hopkin

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thorax, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 3 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 3 syntheses or guidelines pooled it, 376 citations in OpenAlex.

  1. Pooled it
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  16. Article
  17. Early-life antibiotic use and subsequent diagnosis of food allergy and allergic diseases.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2017
    Article
  18. Role of primary and secondary prevention in atopic dermatitis.Postepy dermatologii i alergologii · 2015
    Review
  19. Asthma and allergy in children with and without prior measles, mumps, and rubella vaccination.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2015
    Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

I S FarooqiLung Research Laboratory, Osler Chest Unit, Churchill Hospital, Oxford, UK.
J M Hopkin
Churchill Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtopy is of complex origins but the recent rise in atopic diseases in westernized communities points to the action of important environmental effects. One candidate mechanism is the changing pattern of microbial exposure in childhood. This epidemiological study investigated the relationship between childhood infections and subsequent atopic disease, taking into account a range of social and medical variables.

methodsA total of 1934 subjects representing a retrospective 1975-84 birth group at a family doctor practice in Oxfordshire were studied. Public health and practice records were reviewed; temporal records were made of all diagnoses of infections and their treatments, all immunisations, and diagnoses of asthma, hay fever and eczema; maternal atopy and a number of other variables were documented.

resultsLogistic regression analysis identified three statistically significant predictors of subsequent atopic disease: maternal atopy (1.97, 95% CI 1.46 to 2.66, p < 0.0001), immunisation with whole-cell pertussis vaccine (1.76, 95% CI 1.39 to 2.23, p < 0.0001), and treatment with oral antibiotics in the first two years of life (2.07, 95% CI 1.64 to 2.60, p < 0.0001). There was no significant association found for maternal smoking, bottle feeding, sibship size, or social class.

conclusionsThe prediction of atopic disease by maternal atopy mainly reflects the effect of acknowledged genetic factors. Interpretation of the prediction of atopic disorders by immunisation with wholecell pertussis vaccine and treatment with oral antibiotics needs to be very cautious because of the possibilities of confounding effects and reverse causation. However, plausible immune mechanisms are identifiable for the promotion of atopic disorders by both factors and further investigation of these association is warranted.

Indexed as

Age DistributionAnti-Bacterial AgentsBirth OrderChildChild, PreschoolCohort StudiesFamily PracticeFemaleHumansHypersensitivity, ImmediateInfantInfectionsLogistic ModelsMalePertussis VaccineRetrospective StudiesAnti-Bacterial AgentsPertussis Vaccine

Identifiers

PMID10193389
PMCPMC1745117
OpenAlexW2139188807

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.