ArticleJournal of clinical pathology1998
De novo expression of CD44 in prostate carcinoma is correlated with systemic dissemination of prostate cancer.
Article in Journal of clinical pathology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 35 citations in OpenAlex.
- PanCD44 Immunohistochemical Evaluation in Prostatectomies from Patients with Adenocarcinoma.BioMed research international · 2018Article
- Co-Expression of Putative Cancer Stem Cell Markers CD44 and CD133 in Prostate Carcinomas.Pathology oncology research : POR · 2017Article
- Aerosol delivery of small hairpin osteopontin blocks pulmonary metastasis of breast cancer in mice.PloS one · 2010Article
- Co-expression of CD147 (EMMPRIN), CD44v3-10, MDR1 and monocarboxylate transporters is associated with prostate cancer drug resistance and progression.British journal of cancer · 2010Article
- Gene expression relationship between prostate cancer cells of Gleason 3, 4 and normal epithelial cells as revealed by cell type-specific transcriptomes.BMC cancer · 2009Article
- Characterization of the expression of variant and standard CD44 in prostate cancer cells: identification of the possible molecular mechanism of CD44/MMP9 complex formation on the cell surface.Journal of cellular biochemistry · 2009Article
- Invasive prostate cancer cells are tumor initiating cells that have a stem cell-like genomic signature.Clinical & experimental metastasis · 2009Article
- Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells.Molecular cancer · 2007Article
- Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells.Oncogene · 2006Article
- Identification of leukocyte E-selectin ligands, P-selectin glycoprotein ligand-1 and E-selectin ligand-1, on human metastatic prostate tumor cells.Cancer research · 2005Article
- Prostate epithelial cell lines form spheroids with evidence of glandular differentiation in three-dimensional Matrigel cultures.British journal of cancer · 2001Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo evaluate the role of CD44 in early steps in the development of prostate cancer, and to assess the biological significance of preneoplastic lesions in prostate cancer.
methods38 patients with clinically localised prostate cancer were studied. The standard form of CD44 (CD44H) and v6 isoform expressions were semiquantitatively evaluated on paraffin embedded tumour tissue by immunohistochemistry. Disseminated prostatic cells were detected by prostate specific membrane antigen reverse transcriptase polymerase chain reaction in the blood of each patient before radical prostatectomy.
resultsIn normal or benign prostate glands, only basal cells showed CD44H and v6 labelling. Fourteen of the 38 prostate cancers (37%) had CD44H membranous staining of prostatic tumour cells. In 18 patients (47%), circulating prostatic cells were detected in blood before surgery. Although no correlation between the expression of CD44 and the Gleason score or staging was observed, a significant correlation was found between the expression of CD44H by tumour cells and prostatic cell blood dissemination (p = 0.04). In 28 cases, foci of prostatic intraepithelial neoplasia were observed, and nine had CD44H immunostaining.
conclusionsDe novo expression of CD44 by prostatic tumour cells is associated with systemic dissemination of prostate cells independently of pathological criteria.
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