ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Sympathetic neuronal oscillators are capable of dynamic synchronization.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Human sympathetic outflows to skin and muscle target organs fluctuate concordantly over a wide range of time-varying frequencies.The Journal of physiology · 2012Trial
- Frequency-coded patterns of sympathetic vasomotor activity are differentially evoked by the paraventricular nucleus of the hypothalamus in the Goldblatt hypertension model.Frontiers in cellular neuroscience · 2023Article
- 2019 Ludwig Lecture: Rhythms in sympathetic nerve activity are a key to understanding neural control of the cardiovascular system.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Review
- Deciphering the Neural Control of Sympathetic Nerve Activity: Status Report and Directions for Future Research.Frontiers in neuroscience · 2017Review
- What can we learn about neural control of the cardiovascular system by studying rhythms in sympathetic nerve activity?International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2016Review
- Responses evoked in single sympathetic nerve fibres of the rat tail artery by systemic hypoxia are dependent on core temperature.The Journal of physiology · 2007Article
- Generation of a physiological sympathetic motor rhythm in the rat following spinal application of 5-HT.The Journal of physiology · 2006Article
- Thermoregulatory control of sympathetic fibres supplying the rat's tail.The Journal of physiology · 2002Article
- Frequency response of renal sympathetic nervous activity to aortic depressor nerve stimulation in the anaesthetized rat.The Journal of physiology · 2001Article
- Cold-activated raphé-spinal neurons in rats.The Journal of physiology · 2001Article
- Resetting of sympathetic rhythm by somatic afferents causes post-reflex coordination of sympathetic activity in rat.The Journal of physiology · 2001Article
- Multiple oscillators provide metastability in rhythm generation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Coherent rhythmic discharges in sympathetic nerves supplying thermoregulatory circulations in the rat.The Journal of physiology · 2000Article
- Electrophysiological properties of electrical synapses between rat sympathetic preganglionic neurones in vitro.The Journal of physiology · 1999Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In this paper we show that the discharges of sympathetic neurons innervating an identified peripheral target are driven by multiple oscillators that undergo dynamic synchronization when an entraining force, central respiratory drive (CRD), is increased. Activity was recorded from postganglionic sympathetic neurons (PGNs) innervating the caudal ventral artery of the rat tail: (1) at the population level from the ventral collector nerve (VCN); and (2) from pairs of single PGNs recorded simultaneously using a focal recording technique. Autospectral analysis of VCN activity revealed a more prominent rhythmical component in the presence of CRD than in its absence, suggesting that (1) multiple oscillators drive the discharges of PGNs and (2) these oscillators can be entrained and therefore synchronized by CRD. This interpretation was supported by analysis of the firing behavior of PGN pairs. Autocorrelation and cross-correlation analysis showed that pairs were not synchronized in the absence of CRD but showed significant synchronization when CRD was enhanced. Time-evolving spectral analysis and raster plots demonstrated that the temporal stability of PGN-to-PGN and CRD-to-PGN interactions at a given level of CRD were also dynamic in nature, with stable constant phase relationships predominating as CRD was increased. This is the first reported example of dynamic synchronization in populations of single postganglionic sympathetic neurons, and we suggest that, as in sensory processing and motor control, temporal pattern coding may also be an important feature of neuronal discharges in sympathetic pathways.
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Identifiers
10191331PMC6782266W1631571478What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.