ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 78 citations in OpenAlex.
- Article
- Intracellular chloride channel 1 and tumor.American journal of cancer research · 2023Review
- Insights Into the Role of Mitochondrial Ion Channels in Inflammatory Response.Frontiers in physiology · 2020Review
- A G-Quadruplex Structure in the Promoter Region ofInternational journal of molecular sciences · 2018Article
- Inherent flexibility of CLIC6 revealed by crystallographic and solution studies.Scientific reports · 2018Article
- Anion Channels of Mitochondria.Handbook of experimental pharmacology · 2017Review
- Neuroserpin Differentiates Between Forms of Tissue Type Plasminogen Activator via pH Dependent Deacylation.Frontiers in cellular neuroscience · 2016Article
- Super-resolution imaging of neuronal dense-core vesicles.Journal of visualized experiments : JoVE · 2014Article
- Detection of differential fetal and adult expression of chloride intracellular channel 4 (CLIC4) protein by analysis of a green fluorescent protein knock-in mouse line.BMC developmental biology · 2014Article
- Absence of chloride intracellular channel 4 (CLIC4) predisposes to acute kidney injury but has minimal impact on recovery.BMC nephrology · 2014Article
- CLIC4 is a tumor suppressor for cutaneous squamous cell cancer.Carcinogenesis · 2012Article
- Role of CLIC4 in the host innate responses to bacterial lipopolysaccharide.European journal of immunology · 2011Article
- Chloride intracellular channel 4 is critical for the epithelial morphogenesis of RPE cells and retinal attachment.Molecular biology of the cell · 2010Article
- CLIC5A, a component of the ezrin-podocalyxin complex in glomeruli, is a determinant of podocyte integrity.American journal of physiology. Renal physiology · 2010Article
- Chloride channels of intracellular membranes.FEBS letters · 2010Review
- Enrichment and proteomic analysis of plasma membrane from rat dorsal root ganglions.Proteome science · 2009Article
- Spatiotemporal regulation of chloride intracellular channel protein CLIC4 by RhoA.Molecular biology of the cell · 2009Article
- c-Src control of chloride channel support for osteoclast HCl transport and bone resorption.The Journal of biological chemistry · 2006Article
- Mechanisms of transport and exocytosis of dense-core granules containing tissue plasminogen activator in developing hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Molecular cloning and developmental expression of two Chloride Intracellular Channel (CLIC) genes in Xenopus laevis.Development genes and evolution · 2003Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 4 countries.
Funding
Abstract
A novel class of intracellular chloride channels, the p64 family, has been found on several types of vesicles. These channels, acting in concert with the electrogenic proton pump, regulate the pH of the vesicle interior, which is critical for vesicular function. Here we describe the molecular cloning of p64H1, a p64 homolog, from both human and cow. Northern blot analysis showed that p64H1 is expressed abundantly in brain and retina, whereas the other members of this family (e.g., p64 and NCC27) are expressed only at low levels in these tissues. Immunohistochemical analysis of p64H1 in rat brain, using an affinity-purified antibody, revealed a high level of expression in the limbic system-the hippocampal formation, the amygdala, the hypothalamus, and the septum. Immunoelectron microscopic analysis of p64H1 in hippocampal neurons demonstrated a striking association between p64H1 and large dense-core vesicles (LDCVs) and microtubules. In contrast, very low p64H1 labeling was found in perikarya or associated with small synaptic vesicles (SSVs) in axonal profiles. Immunoblot analysis confirmed that p64H1 is colocalized with heavy membrane fractions containing LDCVs rather than the fractions containing SSVs. These results suggest that p64H1-mediated Cl- permeability may be involved in the maintenance of low internal pH in LDCVs and in the maturation of LDCVs and the biogenesis of functional neuropeptides.
Indexed as
Identifiers
10191309PMC6782274W1543593287What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.