ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Synchronized paroxysmal activity in the developing thalamocortical network mediated by corticothalamic projections and "silent" synapses.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 54 citations in OpenAlex.
- Cell-type-selective synaptogenesis during the development of layer 6 corticothalamic neuron connectivity in the mammalian neocortex.Cell reports · 2026Article
- Axonal connections between S1 barrel, M1, and S2 cortex in the newborn mouse.Frontiers in neuroanatomy · 2023Article
- Cortical afferents onto the nucleus Reticularis thalami promote plasticity of low-threshold excitability through GluN2C-NMDARs.Scientific reports · 2017Article
- NMDA Receptor Expression in the Thalamus of the Stargazer Model of Absence Epilepsy.Scientific reports · 2017Article
- Isolated P/Q Calcium Channel Deletion in Layer VI Corticothalamic Neurons Generates Absence Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Dynamics of networks during absence seizure's on- and offset in rodents and man.Frontiers in physiology · 2015Review
- Expression of Npas4 mRNA in Telencephalic Areas of Adult and Postnatal Mouse Brain.Frontiers in neuroanatomy · 2015Article
- Epileptiform stimulus increases Homer 1a expression to modulate synapse number and activity in hippocampal cultures.Journal of neurophysiology · 2013Article
- Bursts modify electrical synaptic strength.Brain research · 2012Review
- Epileptic stimulus increases Homer 1a expression to modulate endocannabinoid signaling in cultured hippocampal neurons.Neuropharmacology · 2012Article
- Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits.PloS one · 2012Article
- DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation.Human molecular genetics · 2009Article
- Corticofugal modulation of the auditory thalamic reticular nucleus of the guinea pig.The Journal of physiology · 2007Article
- Corticothalamic synchronization leads to c-fos expression in the auditory thalamus.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Effects of cortical stimulation on auditory-responsive thalamic neurones in anaesthetized guinea pigs.The Journal of physiology · 2004Article
- Corticofugal gating of auditory information in the thalamus: an in vivo intracellular recording study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Slow oscillation in non-lemniscal auditory thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Thalamic circuitry and thalamocortical synchrony.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2002Review
- The GABAergic reticular nucleus: a preferential target of corticothalamic projections.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Activity-dependent patterning of retinogeniculate axons proceeds with a constant contribution from AMPA and NMDA receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In mouse thalamocortical slices in vitro, the potassium channel blocker 4-AP and GABAA receptor antagonist bicuculline together induced spontaneous prolonged depolarizations in layer VI neurons from postnatal day 2 (P2), in ventroposterior nucleus neurons (VP) from P7, and in reticular nucleus neurons (RTN) from P8. Dual whole-cell recordings revealed that prolonged bursts were synchronized in layer VI, VP, and RTN. Bursts were present in cortex isolated from thalamus, but not in thalamus isolated from cortex, indicating that bursts originated in cortex and propagated to thalamus. Prolonged bursts were synchronized in layer VI when vertical cuts extended from pia mater through layers IV or V, but were no longer synchronized when cuts extended through layer VI and white matter. In voltage-clamp recordings before P10, burst conductance of all three neuronal populations was dominated by the NMDA receptor-mediated conductance, and therefore synapses were "silent". In cortex and RTN, after P10, bursts were associated with strong AMPA/kainate receptor-mediated conductances, and synapses had become "functional"; silent synapses persisted in a large proportion of VP cells after P10. Before P9, the NMDA receptor antagonist APV or the non-NMDA receptor antagonist CNQX blocked the prolonged bursts. After P9, CNQX continued to block the prolonged bursts, but APV merely shortened their duration. Thus, NMDA receptor-based silent synapses are essential for paroxysmal corticothalamic activity during early postnatal development, and connections between layer VI neurons are sufficient for horizontal cortical synchronization.
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10191304PMC6782276W2122182117What OpenQuestion holds
Registered trials
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