ArticleThe Biochemical journal1999
Identification and characterization of Saccharomyces cerevisiae yapsin 3, a new member of the yapsin family of aspartic proteases encoded by the YPS3 gene.
Article in The Biochemical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 47 citations in OpenAlex.
- The GPI-Anchored Aspartyl Proteases Encoded by theJournal of fungi (Basel, Switzerland) · 2025Article
- Transcriptional response of Saccharomyces cerevisiae to lactic acid enantiomers.Applied microbiology and biotechnology · 2024Article
- Global analysis of Saccharomyces cerevisiae growth in mucin.G3 (Bethesda, Md.) · 2021Article
- Systematic Comparison of Cell Wall-Related Proteins of Different Yeasts.Journal of fungi (Basel, Switzerland) · 2021Article
- Impact of Fungal MAPK Pathway Targets on the Cell Wall.Journal of fungi (Basel, Switzerland) · 2018Article
- Role of the unfolded protein response in regulating the mucin-dependent filamentous-growth mitogen-activated protein kinase pathway.Molecular and cellular biology · 2015Article
- Functional screening system for yeast-secreted peptides acting on G-protein coupled receptors.AMB Express · 2015Article
- Disruption of YPS1 and PEP4 genes reduces proteolytic degradation of secreted HSA/PTH in Pichia pastoris GS115.Journal of industrial microbiology & biotechnology · 2013Article
- A set of aspartyl protease-deficient strains for improved expression of heterologous proteins in Kluyveromyces lactis.FEMS yeast research · 2011Article
- Proteolytic cleavage of covalently linked cell wall proteins by Candida albicans Sap9 and Sap10.Eukaryotic cell · 2011Article
- Novel genes exhibit distinct patterns of function acquisition and network integration.Genome biology · 2010Article
- Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae.Eukaryotic cell · 2005Article
- Reduced proteolysis of secreted gelatin and Yps1-mediated alpha-factor leader processing in a Pichia pastoris kex2 disruptant.Applied and environmental microbiology · 2005Article
- Production of protein-based polymers in Pichia pastoris.Biotechnology advancesReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A new aspartic protease from Saccharomyces cerevisiae, with a high degree of similarity with yapsin 1 and yapsin 2 and a specificity for basic residue cleavage sites of prohormones, has been cloned. This enzyme was named yapsin 3. Expression of a C-terminally truncated non-membrane anchored yapsin 3 in yeast yielded a heterogeneous protein between 135-200 kDa which, upon treatment with endoglycosidase H, migrated as a 60 kDa form. Amino-acid analysis of the N-terminus of expressed yapsin 3 revealed two different N-terminal residues, serine-48 and phenylalanine-54, which followed a dibasic and a monobasic residue respectively. Cleavage of several prohormones by non-anchored yapsin 3 revealed a specificity distinct from that of yapsin 1.
Indexed as
Identifiers
10191273PMC1220171W2067558441What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.