ArticleProceedings. Biological sciences1999
Evidence for mitochondrial DNA recombination in a human population of island Melanesia.
Article in Proceedings. Biological sciences, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 180 citations in OpenAlex.
- Integrated Taxonomy Revealed Genetic Differences in Morphologically Similar and Non-SympatricAnimals : an open access journal from MDPI · 2022Article
- Genetic structure of Kho population from north-western Pakistan based on mtDNA control region sequences.Genetica · 2019Article
- Prevention of mitochondrial genomic instability in yeast by the mitochondrial recombinase Mhr1.Scientific reports · 2019Article
- Cultural inter-population differences do not reflect biological distances: an example of interdisciplinary analysis of populations from Eastern Adriatic coast.Croatian medical journal · 2015Article
- How good are indirect tests at detecting recombination in human mtDNA?G3 (Bethesda, Md.) · 2013Article
- Ancient voyaging and Polynesian origins.American journal of human genetics · 2011Article
- Austronesian genetic signature in East African Madagascar and Polynesia.Journal of human genetics · 2008Article
- The mitochondrial subgenomes of the nematode Globodera pallida are mosaics: evidence of recombination in an animal mitochondrial genome.Journal of molecular evolution · 2007Article
- Deciphering past human population movements in Oceania: provably optimal trees of 127 mtDNA genomes.Molecular biology and evolution · 2006Article
- Mutation hot spots in mammalian mitochondrial DNA.Genome research · 2006Article
- A critical reassessment of the role of mitochondria in tumorigenesis.PLoS medicine · 2005Article
- The evolutionary processes of mitochondrial and chloroplast genomes differ from those of nuclear genomes.Die Naturwissenschaften · 2004Review
- Molecular evolution and recombination in gender-associated mitochondrial DNAs of the Manila clam Tapes philippinarum.Genetics · 2003Article
- South Asia, the Andamanese, and the genetic evidence for an "early" human dispersal out of Africa.American journal of human genetics · 2003Article
- Mitochondrial diabetes mellitus.Journal of endocrinological investigation · 2002Review
- Analysis of European mtDNAs for recombination.American journal of human genetics · 2001Article
- Heteroplasmy in the mtDNA control region of sturgeon (Acipenser, Huso and Scaphirhynchus).Genetics · 2000Article
- Do mitochondria recombine in humans?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2000Review
- Mitochondria, oxidative DNA damage, and aging.Journal of the American Aging Association · 2000Article
- Hypervariable sites in the mtDNA control region are mutational hotspots.American journal of human genetics · 2000Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Mitochondrial DNA (mtDNA) analysis has proved useful in studies of recent human evolution and the genetic affinities of human groups of different geographical regions. As part of an extensive survey of mtDNA diversity in present-day Pacific populations, we obtained sequence information of the hypervariable mtDNA control region of 452 individuals from various localities in the western Pacific. The mtDNA types fell into three major groups which reflect the settlement history of the area. Interestingly, we detected an extremely rare point mutation at high frequency in the small island of Nguna in the Melanesian archipelago of Vanuatu. Phylogenetic analysis of the mtDNA data indicated that the mutation was present in individuals of separate mtDNA lineages. We propose that the multiple occurrence of a rare mutation event in one isolated locality is highly improbable, and that recombination between different mtDNA types is a more likely explanation for our observation. If correct, this conclusion has important implications for the use of mtDNA in phylogenetic and evolutionary studies.
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