ArticleBritish journal of pharmacology1999
Assessment of the effects of endothelin-1 and magnesium sulphate on regional blood flows in conscious rats, by the coloured microsphere reference technique.
Article in British journal of pharmacology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 56 citations in OpenAlex.
- Transdermal iontophoresis versus high power pain threshold ultrasound in Mechanical Neck Pain: a randomized controlled trial.Journal of orthopaedic surgery and research · 2024Trial
- Pharmacological Therapies for Consequences of Perinatal Hypoxic-Ischemic Brain Injury: Where Are We Now?International journal of molecular sciences · 2025Review
- Research on the Current Application Status of Magnesium Metal Stents in Human Luminal Cavities.Journal of functional biomaterials · 2023Review
- Magnesium Sulfate and Cerebral Oxygen Saturation in Mild Traumatic Brain Injury: A Randomized, Double-Blind, Controlled Trial.Journal of clinical medicine · 2022Article
- Effect of magnesium sulfate iontophoresis on myofascial trigger points in the upper fibres of the trapezius.Journal of Taibah University Medical Sciences · 2021Article
- Biosafety and efficacy evaluation of a biodegradable magnesium-based drug-eluting stent in porcine coronary artery.Scientific reports · 2021Article
- Designing Better Cardiovascular Stent Materials - A Learning Curve.Advanced functional materials · 2021Article
- Magnesium sulfate prophylaxis attenuates the postpartum effects of preeclampsia by promoting M2 macrophage polarization.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Magnesium: Pathophysiological mechanisms and potential therapeutic roles in intracerebral hemorrhage.Neural regeneration research · 2019Article
- Magnesium sulfate and ophthalmic artery Doppler velocimetry in patients with severe preeclampsia: a case series.Journal of medical case reports · 2017Article
- Magmaris: a new generation metallic sirolimus-eluting fully bioresorbable scaffold: present status and future perspectives.Journal of thoracic disease · 2017Review
- Incidence, hemodynamic, and electrical characteristics of spreading depolarization in a swine model are affected by local but not by intravenous application of magnesium.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2016Article
- Antenatal Magnesium Sulfate, Necrotizing Enterocolitis, and Death among Neonates < 28 Weeks Gestation.AJP reports · 2016Article
- Aldosterone secretagogues increase adrenal blood flow in male rats.Endocrinology · 2014Article
- Magnesium: potential roles in neurovascular disease.Frontiers in neurology · 2014Review
- Intracisternal infusion of magnesium sulfate solution improved reduced cerebral blood flow induced by experimental subarachnoid hemorrhage in the rat.Neurosurgical review · 2008Article
- Haemodynamic effects of the bacterial quorum sensing signal molecule, N-(3-oxododecanoyl)-L-homoserine lactone, in conscious, normal and endotoxaemic rats.British journal of pharmacology · 2001Article
- Magnesium for neuroprotection in ischaemic stroke: rationale for use and evidence of effectiveness.CNS drugs · 2001Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is evidence to suggest that magnesium (Mg2+) is beneficial in the treatment of a number of conditions, including pre-eclampsia and acute myocardial infarction. The mode of action of Mg2+ in these conditions is not clear, although the vasodilator properties of Mg2+ are well documented both in vitro and in vivo. Previously, we demonstrated that i.v. infusion of magnesium sulphate (MgSO4) alone, or in the presence of vasoconstrictors, caused increases in flow and conductance in the common carotid, internal carotid and hindquarters vascular beds, in conscious rats. Therefore, the objective of the present study was to investigate the regional and subregional changes in haemodynamics in response to the vasoconstrictor peptide endothelin-1 (ET-1) and MgSO4 in more detail, using the coloured microsphere reference technique. Infusion of ET-1 and MgSO4 had similar effects on heart rate and mean arterial pressure as in our previous study. Infusion of ET-1 caused a rise in mean arterial pressure and a fall in heart rate, and infusion of MgSO4 returned mean arterial pressure to control levels with no effect on heart rate. The responses to MgSO4 in the presence of ET-1 showed considerable regional heterogeneity with blood flow increasing (e.g. skeletal muscle), decreasing (e.g. stomach) or not changing (e.g. kidney). Of particular interest was the finding that MgSO4 caused increases in flow in the cerebral and coronary vascular beds. This, and our previous studies, have shown that MgSO4 can reverse vasoconstriction in a number of vascular beds, and indicate that this compound may have therapeutic benefit in conditions associated with vasospasm.
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