ArticleBritish journal of pharmacology1999
Deficiency of nitric oxide in polycation-induced airway hyperreactivity.
Article in British journal of pharmacology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 40 citations in OpenAlex.
- Insulin Modulates the Immune Cell Phenotype in Pulmonary Allergic Inflammation and Increases Pulmonary Resistance in Diabetic Mice.Frontiers in immunology · 2020Article
- Arginase and arginine dysregulation in asthma.Journal of allergy · 2011Article
- Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives.British journal of pharmacology · 2009Review
- Arginine deficiency augments inflammatory mediator production by airway epithelial cells in vitro.Respiratory research · 2009Article
- Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma.Respiratory research · 2006Article
- Heparin normalizes allergen-induced nitric oxide deficiency and airway hyperresponsiveness.British journal of pharmacology · 2004Article
- Multiple roles of nitric oxide in the airways.Thorax · 2003Review
- Effects of the cationic protein poly-L-arginine on airway epithelial cells in vitro.Mediators of inflammation · 2002Article
- Increased arginase activity underlies allergen-induced deficiency of cNOS-derived nitric oxide and airway hyperresponsiveness.British journal of pharmacology · 2002Article
- Role of nitric oxide and superoxide in allergen-induced airway hyperreactivity after the late asthmatic reaction in guinea-pigs.British journal of pharmacology · 2001Article
- Inflammatory cell distribution in guinea pig airways and its relationship to airway reactivity.Mediators of inflammation · 2001Article
- Modulation of cholinergic airway reactivity and nitric oxide production by endogenous arginase activity.British journal of pharmacology · 2000Article
- Role of L-arginine in the deficiency of nitric oxide and airway hyperreactivity after the allergen-induced early asthmatic reaction in guinea-pigs.British journal of pharmacology · 1999Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using a perfused guinea-pig tracheal tube preparation, we investigated the role of endogenous nitric oxide (NO) in polycation-induced airway hyperreactivity (AHR) to methacholine. Intraluminal (IL) administration of the NO synthase inhibitor Nomega-nitro-L-arginine methyl ester (L-NAME; 100 microM) caused a 1.8 fold increase in the maximal contractile response (Emax) to IL methacholine compared to control, without an effect on the pEC50 (-log10 EC50). The polycation poly-L-arginine (100 microg ml(-1), IL) similarly enhanced the Emax for methacholine; however, the pEC50 value was also increased, by one log10 unit. L-NAME had no effect on the enhanced methacholine response of poly-L-arginine-treated airways, while the enhanced agonist response was completely normalized by the polyanion heparin (25 u ml(-1), IL). In addition, the effect of L-NAME was fully restored in the poly-L-arginine plus heparin treated airways. The results indicate that, in addition to enhanced epithelial permeability, a deficiency of endogenous NO contributes to polycation-induced AHR. The latter finding may represent a novel mechanism of AHR induced by eosinophil-derived cationic proteins in allergic asthma.
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