ArticleClinical and experimental immunology1978
Cytotoxicity of human and baboon mononuclear phagocytes against schistosomula in vitro: induction by immune complexes containing IgE and Schistosoma mansoni antigens.
Article in Clinical and experimental immunology, 1978. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 90 citations in OpenAlex.
- Role of adult worm antigen-specific immunoglobulin E in acquired immunity to Schistosoma mansoni infection in baboons.Infection and immunity · 1999Article
- Review
- Potential role for scavenger receptors of human monocytes in the killing of Schistosoma mansoni.The American journal of pathology · 1993Article
- Freshly isolated and cultured human monocytes obtained by plasmapheresis kill schistosomula of Schistosoma mansoni.The American journal of pathology · 1991Article
- IgG subclasses in human chronic schistosomiasis: over-production of schistosome-specific and non-specific IgG4.Clinical and experimental immunology · 1990Article
- Fc epsilon receptor II-positive macrophages and platelets: potent effector cells in allergy and defence against helminth parasites.Springer seminars in immunopathology · 1990Review
- Clinical significance of anti-IgE autoantibodies and immune complexes containing IgE.Clinical reviews in allergy · 1989Review
- IgE and immune defense mechanism.Clinical reviews in allergy · 1989Review
- Human monocyte-derived macrophages are lysed by schistosomula of Schistosoma mansoni and fail to kill the parasite after activation with interferon gamma.The American journal of pathology · 1988Article
- Immunity to Schistosoma mansoni in guinea-pigs vaccinated with radiation-attenuated cercariae. T-cell activation of macrophages for larval killing.Immunology · 1988Article
- Macrophage triggering by aggregated immunoglobulins. II. Comparison of IgE and IgG aggregates or immune complexes.Clinical and experimental immunology · 1984Article
- Cells demonstrating Fc receptors for IgE.Survey of immunologic research · 1984Article
- IgG and IgE circulating immune complexes, total serum IgE and parasite related IgE in patients with mono- or mixed infection with Schistosoma mansoni and/or S. haematobium. Influence of therapy.Clinical and experimental immunology · 1983Article
- Involvement of immunoglobulin E in the secretory processes of alveolar macrophages from asthmatic patients.The Journal of clinical investigation · 1983Article
- Destruction of the multicellular parasite Schistosoma mansoni by T lymphocytes.The Journal of clinical investigation · 1982Article
- Characterization of Fc receptors for IgE on human alveolar macrophages.Clinical and experimental immunology · 1982Article
- Article
- The interaction of IgE antibody with human alveolar macrophages and its participation in the inflammatory processes of lung allergy.Agents and actions · 1981Article
- Macrophages: progress and problems.Clinical and experimental immunology · 1981Review
- IgE-dependent adherence and cytotoxicity of rat spleen and peritoneal cells to Litomosoides carinii microfilariae.Clinical and experimental immunology · 1980Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Normal human blood monocytes, pre-incubated at 37 degrees C with sera from patients infected with Schistosoma mansoni, strongly adhered to S. mansoni schistosomula in vitro, whereas no significant adherence was induced by sera from uninfected individuals. Comparable adherence occurred with normal baboon blood monocytes or peritoneal macrophages when these cells were incubated with sera from S. mansoni-infected baboons. Adherence of macrophages to schistosomula was associated with damage to the larvae, as estimated by a 51Cr release technique. Neither adherence nor cytotoxicity was induced by pre-incubation of the schistosomula, instead of the monocytes, with immune serum. The relevant factor in immune serum was heat-labile, but was not a complement component. Absorption and ultracentrifugation experiments showed that immune complexes, containing S. mansoni-specific IgE antibody and soluble parasite antigens, produced monocyte or macrophage adherence and cytotoxicity. Similar observations have been reported previously in the rat model. Since the production of large amounts of IgE is a predominant feature of schistosome infections in man and experimental animals, it is possible that this new mode of mononuclear phagocyte activation could act as an immune effector mechanism against S. mansoni.
Indexed as
Identifiers
101326PMC1537520W2343910118What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.