ArticleAntimicrobial agents and chemotherapy1999
Alterations in GyrA and ParC associated with fluoroquinolone resistance in Enterococcus faecium.
Article in Antimicrobial agents and chemotherapy, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 68 citations in OpenAlex.
- Clade-specific evolution and genome plasticity underlying antimicrobial resistance in Enterococcus faecium.Archives of microbiology · 2026Review
- Probiotic Characterization of a Novel Enterococcus faecium CPU2401 from Pickles: Unraveling Genomic Mechanisms Underlying the Combating of Oxidative Stress and Infection.Probiotics and antimicrobial proteins · 2026Article
- Efflux pump overexpression in fluoroquinolone multidrug resistance: molecular mechanisms, PK/PD implications, global epidemiology, and translational strategies.Frontiers in pharmacology · 2026Review
- Genomic surveillance of vancomycin-resistant Enterococcus faecium: a study on Resistome, Plasmidome, and mobilome profiling.Current genetics · 2025Article
- Antimicrobial activity of lactic acid bacteria isolated from the gut of African catfish (Clarias gariepinus) against multi-drug-resistant resident pathogens.BMC microbiology · 2025Article
- Fluoroquinolone resistance in ESKAPE pathogens: evolutionary pathways, one health transmission, and clinical surveillance.Frontiers in microbiology · 2025Review
- Non-Clinical microbiology reviews · 2024Review
- Phylogeny, Virulence, and Antimicrobial Resistance Gene Profiles ofAntibiotics (Basel, Switzerland) · 2023Article
- Situational analysis on fluoroquinolones use and characterization of high-level ciprofloxacin-resistantFrontiers in veterinary science · 2023Article
- Update on the Management of Surgical Site Infections.Antibiotics (Basel, Switzerland) · 2022Review
- Review
- Antimicrobial and Biocide Resistance among Canine and FelineAntibiotics (Basel, Switzerland) · 2022Article
- Identification and characterization of resistance and pathogenicity ofWorld journal of clinical pediatrics · 2020Article
- Antimicrobial resistance monitoring of commensal Enterococcus faecalis in broiler breeders.Poultry science · 2020Article
- sraX: A Novel Comprehensive Resistome Analysis Tool.Frontiers in microbiology · 2020Article
- Molecular and phenotypic characterization of enterococci isolated from broiler flocks in Turkey.Tropical animal health and production · 2019Article
- The Enterococcus: a Model of Adaptability to Its Environment.Clinical microbiology reviews · 2019Review
- Draft Genome Sequence of Enterococcus faecalis Strain F165 Isolated from a Urinary Tract Infection.Genome announcements · 2016Article
- Drug-resistant and hospital-associated Enterococcus faecium from wastewater, riverine estuary and anthropogenically impacted marine catchment basin.BMC microbiology · 2014Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-level quinolone resistance in Enterococcus faecium was associated with mutations in both gyrA and parC genes in 10 of 11 resistant strains. On low-level resistant strain without such mutations may instead possess an efflux mechanism or alterations in the other subunits of the gyrase or topoisomerase IV genes. These findings are similar to those for other gram-positive bacteria, such as Enterococcus faecalis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.