ArticleAntimicrobial agents and chemotherapy1999
Antiviral effect of hyperthermic treatment in rhinovirus infection.
Article in Antimicrobial agents and chemotherapy, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 54 citations in OpenAlex.
- Rhinothermy delivered by nasal high flow therapy in the treatment of the common cold: a randomised controlled trial.BMJ open · 2021Trial
- Randomised controlled trial of rhinothermy for treatment of the common cold: a feasibility study.BMJ open · 2018Trial
- Tolerability of Nasal Delivery of Humidified and Warmed Air at Different Temperatures: A Randomised Double-Blind Pilot Study.Pulmonary medicine · 2016Trial
- Visiting a sauna: does inhaling hot dry air reduce common cold symptoms? A randomised controlled trial.The Medical journal of AustraliaTrial
- Nasopharyngeal Airspace Temperature During Rhinothermy.Respiratory care · 2025Article
- Rationale for 1068 nm Photobiomodulation Therapy (PBMT) as a Novel, Non-Invasive Treatment for COVID-19 and Other Coronaviruses: Roles of NO and Hsp70.International journal of molecular sciences · 2022Review
- Review
- Data on steam inhalation in combating CoVid-19.Bioinformation · 2022Article
- Innate immunity, inflammation activation and heat-shock protein in COVID-19 pathogenesis.Journal of neuroimmunology · 2021Review
- Hydrothermotherapy in prevention and treatment of mild to moderate cases of COVID-19.Medical hypotheses · 2021Review
- Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies.Clinical science (London, England : 1979) · 2020Review
- Turning up the heat on COVID-19: heat as a therapeutic intervention.F1000Research · 2020Review
- A Potential Bioelectromagnetic Method to Slow Down the Progression and Prevent the Development of Ultimate Pulmonary Fibrosis by COVID-19.Frontiers in immunology · 2020Review
- Article
- Loss of stress response as a consequence of viral infection: implications for disease and therapy.Cell stress & chaperones · 2012Article
- Lipid metabolism modulation by the P2X7 receptor in the immune system and during the course of infection: new insights into the old view.Purinergic signalling · 2011Article
- HSP70 induced by Hantavirus infection interacts with viral nucleocapsid protein and its overexpression suppresses virus infection in Vero E6 cells.American journal of translational research · 2009Article
- Persistent borna disease virus infection confers instability of HSP70 mRNA in glial cells during heat stress.Journal of virology · 2005Article
- Antiviral effects of geranylgeranylacetone: enhancement of MxA expression and phosphorylation of PKR during influenza virus infection.Antimicrobial agents and chemotherapy · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human rhinoviruses (HRV) are recognized as the major etiologic agents for the common cold. Starting from the observation that local hyperthermic treatment is beneficial in patients with natural and experimental common colds, we have studied the effect of brief hyperthermic treatment (HT) on HRV replication in HeLa cells. We report that a 20-min HT at 45 degrees C is effective in suppressing HRV multiplication by more than 90% when applied at specific stages of the virus replication cycle. Synthesis of virus proteins is not affected by HT, indicating that the target for treatment is a posttranslational event. The antiviral effect is a transient cell-mediated event and is associated with the synthesis of the 70-kDa heat shock protein hsp70. Unlike poliovirus, rhinovirus infection does not inhibit the expression of hsp70 induced by heat. The possibility that hsp70 could play a role in the control of rhinovirus replication is suggested by the fact that a different class of HSP inducers, the cyclopentenone prostaglandins PGA1 and delta 12-PGJ2, were also effective in inhibiting HRV replication in HeLa cells. Inhibition of hsp70 expression by actinomycin D prevented the antiviral activity of prostaglandins in HRV-infected cells. These results indicate that the beneficial effect of respiratory hyperthermia may be mediated by the induction of a cytoprotective heat shock response in rhinovirus-infected cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.