ArticleAntimicrobial agents and chemotherapy1999
Bile salts: natural detergents for the prevention of sexually transmitted diseases.
Article in Antimicrobial agents and chemotherapy, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
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- Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study.Pharmacological reports : PR · 2023Review
- Metabolomics study of COVID-19 patients in four different clinical stages.Scientific reports · 2022Article
- Identification of bile acid and fatty acid species as candidate rapidly bactericidal agents for topical treatment of gonorrhoea.The Journal of antimicrobial chemotherapy · 2021Article
- Roles of bile acids in enteric virus replication.Animal diseases · 2021Review
- Therapeutic uses of animal biles in traditional Chinese medicine: an ethnopharmacological, biophysical chemical and medicinal review.World journal of gastroenterology · 2014Review
- Silencing sexually transmitted infections: topical siRNA-based interventions for the prevention of HIV and HSV.Infectious diseases in obstetrics and gynecology · 2014Review
- Disruption of tight junctions by cellulose sulfate facilitates HIV infection: model of microbicide safety.The Journal of infectious diseases · 2009Article
- Susceptibility of Chlamydia trachomatis to excipients commonly used in topical microbicide formulations.Antimicrobial agents and chemotherapy · 2004Article
- Candidate topical microbicides bind herpes simplex virus glycoprotein B and prevent viral entry and cell-to-cell spread.Antimicrobial agents and chemotherapy · 2004Article
- Herpes simplex virus triggers activation of calcium-signaling pathways.The Journal of cell biology · 2003Article
- NP-1, a rabbit alpha-defensin, prevents the entry and intercellular spread of herpes simplex virus type 2.Antimicrobial agents and chemotherapy · 2003Article
- Mandelic acid condensation polymer: novel candidate microbicide for prevention of human immunodeficiency virus and herpes simplex virus entry.Journal of virology · 2002Article
- Comparative study of mechanisms of herpes simplex virus inactivation by sodium lauryl sulfate and n-lauroylsarcosine.Antimicrobial agents and chemotherapy · 2002Article
- Thermoreversible gel formulations containing sodium lauryl sulfate or n-Lauroylsarcosine as potential topical microbicides against sexually transmitted diseases.Antimicrobial agents and chemotherapy · 2001Article
- Pharmacology of bile acids and their derivatives: absorption promoters and therapeutic agents.European journal of drug metabolism and pharmacokineticsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The development of new, safe, topical microbicides for intravaginal use for the prevention of sexually transmitted diseases is imperative. Previous studies have suggested that bile salts may inhibit human immunodeficiency virus infection; however, their activities against other sexually transmitted pathogens have not been reported. To further explore the potential role of bile salts in preventing sexually transmitted diseases, we examined the in vitro activities and cytotoxicities of select bile salts against Chlamydia trachomatis, herpes simplex virus (types 1 and 2), Neisseria gonorrhoeae, and human immunodeficiency virus in comparison to those of nonoxynol-9 and benzalkonium chloride using both primary cells and cell lines derived from the human female genital tract. We found that taurolithocholic acid 3-sulfate and a combination of glycocholic acid and taurolithocholic acid 3-sulfate showed excellent activity against all of the pathogens assayed. Moreover, taurolithocholic acid 3-sulfate alone or in combination was less cytotoxic than nonoxynol-9 and benzalkonium chloride. Thus, taurolithocholic acid 3-sulfate alone or in combination warrants further evaluation as a candidate topical microbicidal agent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.