Evidence map›Paper›PMID 10102635›Full record

ArticleOncogene1999

GTPase deficient mutant of G(alpha13) regulates the expression of Egr-1 through the small GTPase Rho.

M V Vara Prasad, N Dhanasekaran

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Role of G12 proteins in oncogenesis and metastasis.British journal of pharmacology · 2009
    Review
  4. Article
  5. Interaction of G alpha(12) with G alpha(13) and G alpha(q) signaling pathways.Proceedings of the National Academy of Sciences of the United States of America · 2002
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

M V Vara PrasadFels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
N Dhanasekaran
Temple University · US

Funding

NIGMS NIH HHS GM 49897
6 · The paper itself

Abstract

The alpha-subunit of the heterotrimeric G protein G13 regulate cell growth, differentiation and apoptosis in different cell types. Expression of the constitutively activated mutant of G(alpha)13 (G(alpha13)QL) increases the expression of Egr-1, an immediate-early response gene that is identified to be involved in cell growth, differentiation, and apoptosis. Here we report that G(alpha13)QL activates the promoter of Egr-1 through specific sequence which includes the characteristic CArG boxes. We also demonstrate that the G(alpha13)QL activation of Egr-1 promoter is mediated by the Ras-like small GTPase Rho.

Indexed as

Immediate-Early Proteins3T3 CellsAnimalsDNA-Binding ProteinsEarly Growth Response Protein 1Enzyme InductionGenes, Immediate-EarlyGenes, ReporterGTP-Binding Protein alpha Subunits, G12-G13GTP-Binding ProteinsMicePromoter Regions, GeneticRecombinant Fusion Proteinsrho GTP-Binding ProteinsSignal TransductionTranscription FactorsDNA-Binding ProteinsEarly Growth Response Protein 1Egr1 protein, mouseGTP-Binding Protein alpha Subunits, G12-G13GTP-Binding ProteinsImmediate-Early ProteinsRecombinant Fusion Proteinsrho GTP-Binding ProteinsTranscription Factors

Identifiers

PMID10102635
OpenAlexW2314474185

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.