ArticleOncogene1999
P53-dependent and -independent links between DNA-damage, apoptosis and mutation frequency in ES cells.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 74 citations in OpenAlex.
- Novel kinetic and developmental transcriptomic pan-stress responses by embryonic stem cells.Scientific reports · 2025Article
- Cell Death and the p53 Enigma During Mammalian Embryonic Development.Stem cells (Dayton, Ohio) · 2022Review
- Why stem/progenitor cells lose their regenerative potential.World journal of stem cells · 2021Review
- Developmental Acquisition ofGenes · 2021Review
- Babam2 Regulates Cell Cycle Progression and Pluripotency in Mouse Embryonic Stem Cells as Revealed by Induced DNA Damage.Biomedicines · 2020Article
- p53 Is Active in Human Amniotic Fluid Stem Cells.Stem cells and development · 2018Article
- Ronin influences the DNA damage response in pluripotent stem cells.Stem cell research · 2017Article
- G1 checkpoint is compromised in mouse ESCs due to functional uncoupling of p53-p21Waf1 signaling.Cell cycle (Georgetown, Tex.) · 2016Article
- Stem cells: the pursuit of genomic stability.International journal of molecular sciences · 2014Review
- Metabolic regulation of redox status in stem cells.Antioxidants & redox signaling · 2014Review
- Molecular mechanisms controlling the cell cycle in embryonic stem cells.Stem cell reviews and reports · 2013Review
- Apoptotic susceptibility to DNA damage of pluripotent stem cells facilitates pharmacologic purging of teratoma risk.Stem cells translational medicine · 2012Article
- Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells.Nucleic acids research · 2012Article
- Sin3a is essential for the genome integrity and viability of pluripotent cells.Developmental biology · 2012Article
- Genome-wide profiling of pluripotent cells reveals a unique molecular signature of human embryonic germ cells.PloS one · 2012Article
- p53 in stem cells.World journal of biological chemistry · 2011Article
- Article
- TRANSCRIPTIONAL AND PHOSPHO-PROTEOMIC SCREENS REVEAL STEM CELL ACTIVATION OF INSULIN-RESISTANCE AND TRANSFORMATION PATHWAYS FOLLOWING A SINGLE MINIMALLY TOXIC EPISODE OF ROS.International journal of genomics and proteomics · 2011Article
- Viral single-strand DNA induces p53-dependent apoptosis in human embryonic stem cells.PloS one · 2011Article
- Mouse embryonic stem cells, but not somatic cells, predominantly use homologous recombination to repair double-strand DNA breaks.Stem cells and development · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hypothesis that p53 deficiency enhances the survival of DNA-damage bearing cells was investigated in wild-type and p53 mutant embryonic stem (ES) cells. Following UV-C irradiation, p53 is rapidly induced in wild-type cells and p53-dependent apoptosis follows within 8 h, resulting in the death of the majority of cells within 36 h. Increasing doses of UV-irradiation resulted in enhanced clonogenic survival of null cells as compared to wild-type. Amongst surviving clones, the Hprt mutation frequency was found to be dependent upon UV dose and influenced by p53 status. Treatment with ionizing radiation led to enhanced expression of p53 but resulted in little induction of apoptosis irrespective of p53 status. However, clonogenic potential was considerably reduced, particularly in wild-type cells which showed a tenfold lower survival than null cells. In contrast to the effects of UV-irradiation, the incidence of Hprt mutation did not differ significantly between wild-type and p53 null survivors. The data confirm that p53 restricts the numbers of cells bearing mutations that survive DNA damage induced by either agent, albeit by different mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.