ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne1999
Diagnosis and management of acute alcohol withdrawal.
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04156464 (Phenobarbital Versus Ativan for Refractory Alcohol Withdrawal Treatment in the Intensive Care Unit), which is not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phenobarbital Versus Ativan for Refractory Alcohol Withdrawal Treatment in the Intensive Care Unit
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Meta-analysis of benzodiazepine use in the treatment of insomnia.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2000Pooled it
- Meta-analysis of benzodiazepine use in the treatment of acute alcohol withdrawal.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 1999Pooled it
- Continuous alcohol withdrawal delirium and physical illness-associated delirium in a man brought to the emergency department after a disaster: A case report.Neuropsychopharmacology reports · 2024Article
- Protein kinase C epsilon-mediated modulation of T-type calcium channels underlies alcohol withdrawal hyperexcitability in the midline thalamus.Alcohol, clinical & experimental research · 2024Article
- Telehealth interventions to reduce alcohol use in men with HIV who have sex with men: Protocol for a factorial randomized controlled trial.Contemporary clinical trials communications · 2019Article
- Treatment of Alcohol Withdrawal Syndrome with and without Dexmedetomidine.The Permanente journal · 2016Article
- Alcohol Withdrawal Syndrome: Benzodiazepines and Beyond.Journal of clinical and diagnostic research : JCDR · 2015Review
- Improving alcohol withdrawal outcomes in acute care.The Permanente journal · 2014Article
- Evaluation of an alcohol withdrawal protocol and a preprinted order set at a tertiary care hospital.The Canadian journal of hospital pharmacy · 2011Article
- Association analysis of the GABA(A) receptor subunit genes cluster on 5q33-34 and alcohol dependence in a Japanese population.Molecular psychiatry · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alcohol abuse produces a considerable burden of illness in the Canadian population. The diagnosis of alcohol dependence and withdrawal can be difficult, particularly in the setting of covert intake or comorbidity. Two validated scales, the CAGE questionnaire to screen for alcohol abuse and dependence and the Clinical Institute Withdrawal Assessment for Alcohol (CIWA-Ar) scale to assess the severity of withdrawal, are valuable tools for clinicians to use on a regular basis. For the treatment of alcohol withdrawal, compelling anecdotal evidence supports the routine administration of thiamine, but not necessarily other vitamins. Phenytoin has not been shown to be superior to placebo for uncomplicated withdrawal seizures. Neuroleptics are not recommended for routine use. Sedation with benzodiazepines guided by the CIWA-Ar results is recommended. There is good evidence that the management of alcohol withdrawal can be improved with the routine use of the CIWA-Ar scale to assess severity, treatment with adequate doses of benzodiazepines and follow-up monitoring of patients in alcohol withdrawal.
Indexed as
Identifiers
10102003PMC1230114W2125927660What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.