ArticleGenetics1999
Suppression of intrachromosomal gene conversion in mammalian cells by small degrees of sequence divergence.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 70 citations in OpenAlex.
- Recursive Ectopic Gene Conversion Leads to Elevated DNA Mutation, Gene Loss, and Novel Gene Formation inMicroorganisms · 2025Article
- Article
- The Evolution of Widespread Recombination Suppression on the Dwarf Hamster (Phodopus) X Chromosome.Genome biology and evolution · 2022Article
- Identification of structural variation and polymorphisms of a sex co-segregating scaffold in spinach.Plant reproduction · 2022Article
- Alteration of genetic recombination and double-strand break repair in human cells by progerin expression.DNA repair · 2020Article
- Interlocus gene conversion explains at least 2.7% of single nucleotide variants in human segmental duplications.BMC genomics · 2015Article
- Induction of recombination between diverged sequences in a mammalian genome by a double-strand break.Cellular and molecular life sciences : CMLS · 2014Article
- Gene conversion yields novel gene combinations in paralogs of GOT1 in the copepod Tigriopus californicus.BMC evolutionary biology · 2013Article
- Article
- Strong purifying selection against gene conversions in the trypsin genes of primates.Human genetics · 2012Article
- A strong deletion bias in nonallelic gene conversion.PLoS genetics · 2012Article
- Article
- Minimal effect of ectopic gene conversion among recent duplicates in four mammalian genomes.Genetics · 2009Article
- Genetic diversity in the Paramecium aurelia species complex.Molecular biology and evolution · 2009Article
- Detailed recombination studies along chromosome 3B provide new insights on crossover distribution in wheat (Triticum aestivum L.).Genetics · 2009Article
- Genomic complexity of the Y-STR DYS19: inversions, deletions and founder lineages carrying duplications.International journal of legal medicine · 2009Article
- Accurate homologous recombination is a prominent double-strand break repair pathway in mammalian chromosomes and is modulated by mismatch repair protein Msh2.Molecular and cellular biology · 2007Article
- Rate of recombinational deletion among human endogenous retroviruses.Journal of virology · 2007Article
- Predicting the size of the progeny mapping population required to positionally clone a gene.Genetics · 2007Article
- Structural variation on the short arm of the human Y chromosome: recurrent multigene deletions encompassing Amelogenin Y.Human molecular genetics · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Pairs of closely linked defective herpes simplex virus (HSV) thymidine kinase (tk) gene sequences exhibiting various nucleotide heterologies were introduced into the genome of mouse Ltk- cells. Recombination events were recovered by selecting for the correction of a 16-bp insertion mutation in one of the tk sequences. We had previously shown that when two tk sequences shared a region of 232 bp of homology, interruption of the homology by two single nucleotide heterologies placed 19 bp apart reduced recombination nearly 20-fold. We now report that either one of the nucleotide heterologies alone reduces recombination only about 2.5-fold, indicating that the original pair of single nucleotide heterologies acted synergistically to inhibit recombination. We tested a variety of pairs of single nucleotide heterologies and determined that they reduced recombination from 7- to 175-fold. Substrates potentially leading to G-G or C-C mispairs in presumptive heteroduplex DNA (hDNA) intermediates displayed a particularly low rate of recombination. Additional experiments suggested that increased sequence divergence causes a shortening of gene conversion tracts. Collectively, our results suggest that suppression of recombination between diverged sequences is mediated via processing of a mispaired hDNA intermediate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.