ArticleGenetics1999
Trans-acting factors required for inclusion of regulated exons in the Ultrabithorax mRNAs of Drosophila melanogaster.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed.
- Theme and variation in the evolution of insect sex determination.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2023Review
- The RNA mCell death & disease · 2022Review
- Molecular and genetic dissection of recursive splicing.Life science alliance · 2022Article
- An Interaction Network of RNA-Binding Proteins Involved inMolecular & cellular proteomics : MCP · 2020Article
- The Drosophila Wilms׳ Tumor 1-Associating Protein (WTAP) homolog is required for eye development.Developmental biology · 2014Article
- Wolbachia infections in Anopheles gambiae cells: transcriptomic characterization of a novel host-symbiont interaction.PLoS pathogens · 2011Article
- Comparing peripheral glial cell differentiation in Drosophila and vertebrates.Cellular and molecular life sciences : CMLS · 2011Review
- Hrp48 attenuates Sxl expression to allow for proper notch expression and signaling in wing development.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Article
- Nuclear degradation of Wilms tumor 1-associating protein and survivin splice variant switching underlie IGF-1-mediated survival.The Journal of biological chemistry · 2009Article
- Glorund interactions in the regulation of gurken and oskar mRNAs.Developmental biology · 2009Article
- Functioning of the Drosophila Wilms'-tumor-1-associated protein homolog, Fl(2)d, in Sex-lethal-dependent alternative splicing.Genetics · 2008Article
- A sensitized PiggyBac-based screen for regulators of border cell migration in Drosophila.Genetics · 2007Article
- A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway.Nature genetics · 2005Article
- Global analysis of positive and negative pre-mRNA splicing regulators in Drosophila.Genes & development · 2005Article
- Functional studies on the ATM intronic splicing processing element.Nucleic acids research · 2005Article
- Suppressor of sable, a putative RNA-processing protein, functions at the level of transcription.Molecular and cellular biology · 2004Article
- RNA binding protein sex-lethal (Sxl) and control of Drosophila sex determination and dosage compensation.Microbiology and molecular biology reviews : MMBR · 2003Review
- Cryptococcus neoformans with a mutation in the tetratricopeptide repeat-containing gene, CCN1, causes subcutaneous lesions but fails to cause systemic infection.Infection and immunity · 2003Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Alternatively spliced Ultrabithorax mRNAs differ by the presence of internal exons mI and mII. Two approaches were used to identify trans-acting factors required for inclusion of these cassette exons. First, mutations in a set of genes implicated in the control of other alternative splicing decisions were tested for dominant effects on the Ubx alternative splicing pattern. To identify additional genes involved in regulation of Ubx splicing, a large collection of deficiencies was tested first for dominant enhancement of the haploinsufficient Ubx haltere phenotype and second for effects on the splicing pattern. Inclusion of the cassette exons in Ubx mRNAs was reduced strongly in heterozygotes for hypomorphic alleles of hrp48, which encodes a member of the hnRNP A/B family and is implicated in control of P-element splicing. Significant reductions of mI and mII inclusion were also observed in heterozygotes for loss-of-function alleles of virilizer, fl(2)d, and crooked neck. The products of virilizer and fl(2)d are also required for Sxl autoregulation at the level of splicing; crooked neck encodes a protein with structural similarities to yeast-splicing factors Prp39p and Prp42p. Deletion of at least five other loci caused significant reductions in the inclusion of mI and/or mII. Possible roles of identified factors are discussed in the context of the resplicing strategy for generation of alternative Ubx mRNAs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.