ReviewMolecular and cellular biochemistry1999
Actin binding proteins that change extent and rate of actin monomer-polymer distribution by different mechanisms.
Review in Molecular and cellular biochemistry, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- New Model for Stacking Monomers in Filamentous Actin from Skeletal Muscles ofInternational journal of molecular sciences · 2020Article
- Heterogeneous Porphyromonas gingivalis LPS modulates immuno-inflammatory response, antioxidant defense and cytoskeletal dynamics in human gingival fibroblasts.Scientific reports · 2016Article
- A repeat unit of Vibrio diarrheal T3S effector subverts cytoskeletal actin homeostasis via binding to interstrand region of actin filaments.Scientific reports · 2015Article
- Memories of Annemarie Weber.Anatomical record (Hoboken, N.J. : 2007) · 2014Article
- The IQGAP-related protein DGAP1 mediates signaling to the actin cytoskeleton as an effector and a sequestrator of Rac1 GTPases.Cellular and molecular life sciences : CMLS · 2014Article
- Muscle giants: molecular scaffolds in sarcomerogenesis.Physiological reviews · 2009Review
- Effect of profilin on actin critical concentration: a theoretical analysis.Biophysical journal · 2008Article
- Relating microstructure to rheology of a bundled and cross-linked F-actin network in vitro.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The interaction of tropomodulin with tropomyosin stabilizes thin filaments in cardiac myocytes.The Journal of cell biology · 2003Article
- Cofilin and DNase I affect the conformation of the small domain of actin.Biophysical journal · 2002Article
- Secretion and assembly of zona pellucida glycoproteins by growing mouse oocytes microinjected with epitope-tagged cDNAs for mZP2 and mZP3.Molecular biology of the cell · 2002Article
- Sound attenuation of polymerizing actin reflects supramolecular structures: viscoelastic properties of actin gels modified by cytochalasin D, profilin and alpha-actinin.The Biochemical journal · 2001Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Actin binding proteins control actin assembly and disassembly by altering the critical concentration and by changing the kinetics of polymerization. All of these control mechanisms in some way or the other make use of the energy of hydrolysis of actin-bound ATP. Capping of barbed filament ends increases the critical concentration as long as ATP hydrolysis maintains a difference in the actin monomer binding constants of the two ends. A further increase in the critical concentration on adding a second cap, tropomodulin, to the other, pointed filament end also requires ATP hydrolysis as described by the model presented here. Changes in the critical concentration are amplified into much larger changes of the monomer pool by actin sequestering proteins, provided their actin binding equilibrium constants fall within a relatively narrow range around the values for the two critical concentrations of actin. Cofilin greatly speeds up treadmilling, which requires ATP hydroysis, by increasing the rate constant of depolymerization. Profilin increases the rate of elongation at the barbed filament end, coupled to a lowering of the critical concentration, only if ATP hydrolysis makes profilin binding to the barbed end independent of its binding constant for actin monomers.
Indexed as
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10098971What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.