ArticleBritish journal of cancer1999
Prognostic value of p53 protein expression for patients with gastric cancer--a multivariate analysis.
Article in British journal of cancer, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- The prognostic significance of p53 expression in gastric cancer: a meta-analysis.Journal of cancer research and clinical oncology · 2015Pooled it
- New molecular staging with G-factors (VEGF-C and Reg IV) by supplementing TNM classification in colorectal cancers.Oncology reports · 2013Pooled it
- Intestinal-type gastric dysplasia in Helicobacter pylori-naïve patients.Virchows Archiv : an international journal of pathology · 2022Article
- Isoforms of the p53 Family and Gastric Cancer: A Ménage à Trois for an Unfinished Affair.Cancers · 2021Review
- Prediction of TP53 mutations by p53 immunohistochemistry and their prognostic significance in gastric cancer.Journal of pathology and translational medicine · 2020Article
- Overexpression of MTH1 and OGG1 proteins in ulcerative colitis-associated carcinogenesis.Oncology letters · 2018Article
- New molecular staging with G-factor supplements TNM classification in gastric cancer: a multicenter collaborative research by the Japan Society for Gastroenterological Carcinogenesis G-Project committee.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2015Article
- Synergistic role between p53 and JWA: prognostic and predictive biomarkers in gastric cancer.PloS one · 2012Article
- Prognostic significance of p53 protein expression in early gastric cancer.Pathology oncology research : POR · 2011Article
- The prognostic significance of apoptosis-related biological markers in Chinese gastric cancer patients.PloS one · 2011Article
- Relationship between VEGF and p53 expression and tumor cell proliferation in human gastrointestinal carcinomas.Journal of cancer research and clinical oncology · 2008Article
- Prognostic significance of immunohistochemical expression of p53 and retinoblastoma gene protein (pRB) in curatively resected gastric cancer.The Korean journal of internal medicine · 2005Article
- p53 and VEGF expression are independent predictors of tumour recurrence and survival following curative resection of gastric cancer.British journal of cancer · 2004Article
- Prognostic significance of Bcl-2 and p53 expression in gastric cancer.International journal of colorectal disease · 2003Article
- Association of color Doppler vascularity index and microvessel density with survival in patients with gastric cancer.Annals of surgery · 2002Article
- Clinicopathologic association of cyclooxygenase 1 and cyclooxygenase 2 expression in gastric adenocarcinoma.Annals of surgery · 2001Article
- Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection, histological types and staging.World journal of gastroenterology · 2000Article
- The prognostic value of UHRF-1 and p53 in gastric cancer.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutations in the p53 gene, one of the most common genetic alterations in human cancer, are implicated in tumorigenesis and tumour progression. Although p53 protein expression appears to be correlated to prognosis in patients with malignancy, its prognostic role in gastric cancer has remained controversial. We examined the clinical significance of p53 overexpression in 427 patients with gastric cancer, using multivariate analysis. Tumour sections of gastric cancer tissues from these 427 Japanese patients were stained immunohistochemically with monoclonal antibody PAb1801. The presence of p53 expression was statistically compared with clinicopathological features and post-operative survival, using univariate and multivariate analyses. p53 expression was detected in 38.6% (165 out of 427) of these gastric cancers and immunoreactivity was not observed in normal mucosa adjacent to the tumour. A higher rate of p53 detection was observed among large tumours and in those with a prominent depth of invasion, lymphatic and vascular invasion and lymph node involvement. Prognosis was significantly worse for patients with p53-positive-staining tumours. The 5-year survival rate was 62.5% for patients with p53-negative tumours and 43.3% for those with positive malignancies. p53 expression was a significant prognostic factor for node-positive gastric cancers in subjects undergoing treatment with curative resection, as assessed by Cox regression analysis. Thus, the expression of p53 was closely related to the potential for tumour advance and a poorer post-operative prognosis for patients with gastric cancer.
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