ArticleProceedings. Biological sciences1999
Virulence evolution in a virus obeys a trade-off.
Article in Proceedings. Biological sciences, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Correlates of viral richness in bats (order Chiroptera).EcoHealth · 2009Pooled it
- Virulence evolution of a salmonid virus following a host jump.PLoS pathogens · 2025Article
- Totivirus-satellite coinfection prevalence and host genotype associations in wild Saccharomyces cerevisiae.FEMS microbiology ecology · 2025Article
- Host responses and viral traits interact to shape the impacts of climate warming on highly pathogenic avian influenza in migratory waterfowl.PLoS computational biology · 2025Article
- Evolution into chaos - Implications of the trade-off between transmissibility and immune evasion.Infectious Disease Modelling · 2025Article
- Complex interactions in the life cycle of a simple parasite shape the evolution of virulence.PLoS pathogens · 2025Article
- Dissecting transmission to understand parasite evolution.PLoS pathogens · 2025Review
- The evolutionary cost of homophily: Social stratification facilitates stable variant coexistence and increased rates of evolution in host-associated pathogens.PLoS computational biology · 2024Article
- Multispecies interactions and the community context of the evolution of virulence.Proceedings. Biological sciences · 2024Article
- The evolutionary cost of homophily: social stratification facilitates stable variant coexistence and increased rates of evolution in host-associated pathogens.bioRxiv : the preprint server for biology · 2024Article
- Emerging evidence of seed transmission of begomoviruses: implications in global circulation and disease outbreak.Frontiers in plant science · 2024Review
- Death is overrated: the potential role of detection in driving virulence evolution.Proceedings. Biological sciences · 2023Article
- Infection burdens and virulence under heat stress: ecological and evolutionary considerations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Higher phage virulence accelerates the evolution of host resistance.Proceedings. Biological sciences · 2022Article
- Structural bioinformatics analysis of SARS-CoV-2 variants reveals higher hACE2 receptor binding affinity for Omicron B.1.1.529 spike RBD compared to wild type reference.Scientific reports · 2022Article
- Increased copy number couples the evolution of plasmid horizontal transmission and plasmid-encoded antibiotic resistance.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The dynamics of evolutionary rescue from a novel pathogen threat in a host metapopulation.Scientific reports · 2021Article
- Virus shedding kinetics and unconventional virulence tradeoffs.PLoS pathogens · 2021Article
- Bidirectional interactions between host social behaviour and parasites arise through ecological and evolutionary processes.Parasitology · 2021Article
- Molecular causes of an evolutionary shift along the parasitism-mutualism continuum in a bacterial symbiont.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolution of virulence was studied in a virus subjected to alternating episodes of vertical and horizontal transmission. Bacteriophage f1 was used as the parasite because it establishes a debilitating but non-fatal infection that can be transmitted vertically (from a host to its progeny) as well as horizontally (infection of new hosts). Horizontal transmission was required of all phage at specific intervals, but was prevented otherwise. Each episode of horizontal transmission was followed by an interval of obligate vertical transmission, followed by an interval of obligate horizontal transmission etc. The duration of vertical transmission was eight times longer per episode in one treatment than in the other, thus varying the relative intensity of selection against virulence while maintaining selection for some level of virus production. Viral lines with the higher enforced rate of infectious transmission evolved higher virulence and higher rates of virus production. These results support the trade-off model for the evolution of virulence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.