ArticleProceedings of the National Academy of Sciences of the United States of America1999
Long-range signaling within growing neurites mediated by neurotrophin-3.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 25 citations in OpenAlex.
- Presynaptic protein synthesis required for NT-3-induced long-term synaptic modulation.Molecular brain · 2011Article
- Model of neurotransmitter fast transport in axon terminal of presynaptic neuron.Journal of mathematical biology · 2008Article
- Distinct mechanisms for neurotrophin-3-induced acute and long-term synaptic potentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Brain repair and neuroprotection by serum insulin-like growth factor I.Molecular neurobiology · 2003Review
- Synaptic reliability correlates with reduced susceptibility to synaptic potentiation by brain-derived neurotrophic factor.Learning & memory (Cold Spring Harbor, N.Y.)Article
- BDNF and activity-dependent synaptic modulation.Learning & memory (Cold Spring Harbor, N.Y.)Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In addition to well established trophic functions, neurotrophins acutely affect neurotransmitter secretion from the presynaptic nerve terminal, influence synaptic development, and may serve as selective retrograde messengers that regulate synaptic efficacy. The crucial question related to the mechanisms of neurotrophin-mediated signaling is whether acute effects of neurotrophins are spatially restricted to the activated synapses. Here we have used a local perfusion technique for local delivery of neurotrophin-3 (NT-3) to various regions of developing Xenopus embryo neurons in culture. Within minutes after a focal exposure of a soma or a small ( approximately 30 micrometer in length) axonal segment to NT-3, we observed an increase in the spontaneous neurotransmitter secretion from the presynaptic nerve terminals located approximately 300-400 micrometer away from the site of NT-3 application. Secretory activity along the axonal shaft was not affected. Our findings suggest that the NT-3-mediated signal may rapidly travel through neuronal cytoplasm over unexpectedly long distances and modulate neurotransmitter release specifically at the presynaptic nerve terminals.
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Registered trials
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