ArticleProceedings of the National Academy of Sciences of the United States of America1999
The p42 variant of ETS1 protein rescues defective Fas-induced apoptosis in colon carcinoma cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- ETS1 Protein Expression May Be Altered by the Complementarity of ETS1 mRNA Sequences with miR-203a-3p and miR-204-3p in Papillary Thyroid Carcinoma.International journal of molecular sciences · 2025Article
- Circular RNA_0000326 promotes bladder cancer progression via microRNA-338-3p/ETS Proto-Oncogene 1/phosphoinositide-3 kinase/Akt pathway.Bioengineered · 2021Article
- A Role for Autoinhibition in Preventing Dimerization of the Transcription Factor ETS1.The Journal of biological chemistry · 2015Article
- Oncogenic role of EAPII in lung cancer development and its activation of the MAPK-ERK pathway.Oncogene · 2011Article
- Article
- A role for mitogen-activated protein kinase and Ets-1 in the induction of interleukin-10 transcription by human immunodeficiency virus-1 Tat.Immunology · 2007Article
- Expression of X-linked inhibitor of apoptosis protein and its effect on chemotherapeutic sensitivity of bladder carcinoma.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2007Article
- Thymomegaly, microsplenia, and defective homeostatic proliferation of peripheral lymphocytes in p51-Ets1 isoform-specific null mice.Molecular and cellular biology · 2007Article
- Caspase-1 is a direct target gene of ETS1 and plays a role in ETS1-induced apoptosis.Cancer research · 2005Article
- SP100 inhibits ETS1 activity in primary endothelial cells.Oncogene · 2005Article
- Overexpression of the Ets-1 transcription factor in human breast cancer.British journal of cancer · 2004Article
- Article
- ETS transcription factors: possible targets for cancer therapy.Cancer science · 2004Review
- Characterization and functional analysis of the p42Ets-1 variant of the mouse Ets-1 transcription factor.Oncogene · 2003Article
- The biology of the Ets1 proto-oncogene.Molecular cancer · 2003Review
- Article
- Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells.The EMBO journal · 2002Article
- The Ets-transcription factor family in embryonic development: lessons from the amphibian and bird.Oncogene · 2000Review
- Ets target genes: past, present and future.Oncogene · 2000Review
- Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
ETS1 is a cellular homologue of the product of the viral ets oncogene of the E26 virus, and it functions as a tissue-specific transcription factor. It plays an important role in cell proliferation, differentiation, lymphoid cell development, transformation, angiogenesis, and apoptosis. ETS1 controls the expression of critical genes involved in these processes by binding to ets binding sites present in the transcriptional regulatory regions. The ETS1 gene generates two proteins, p51 and a spliced variant, p42, lacking exon VII. In this paper we show that p42-ETS1 expression bypasses the damaged Fas-induced apoptotic pathway in DLD1 colon carcinoma cells by up-regulating interleukin 1beta-converting enzyme (ICE)/caspase-1 and causes these cancer cells to become susceptible to the effects of the normal apoptosis activation system. ICE/caspase-1 is a redundant system in many cells and tissues, and here we demonstrate that it is important in activating apoptosis in cells where the normal apoptosis pathway is blocked. Blocking ICE/caspase-1 activity by using specific inhibitors of this protease prevents the p42-ETS1-induced apoptosis from occurring, indicating that the induced ICE/caspase-1 enzyme is responsible for killing the cancer cells. p42-ETS1 activates a critical alternative apoptosis pathway in cancer cells that are resistant to normal immune attack, and thus it may be useful as an anticancer therapeutic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.