ArticleProceedings of the National Academy of Sciences of the United States of America1999
Distribution of haplotypes from a chromosome 21 region distinguishes multiple prehistoric human migrations.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 99 citations in OpenAlex.
- Interbreeding between farmers and hunter-gatherers along the inland and Mediterranean routes of Neolithic spread in Europe.Nature communications · 2024Article
- Inner and inter population structure construction of Chinese Jiangsu Han population based on Y23 STR system.PloS one · 2017Article
- The Specificity Principle in Acculturation Science.Perspectives on psychological science : a journal of the Association for Psychological Science · 2017Review
- Molecular adaptation of modern human populations.International journal of evolutionary biology · 2010Article
- Support from the relationship of genetic and geographic distance in human populations for a serial founder effect originating in Africa.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Chinese strains (Type 7) of JC virus are afro-asiatic in origin but are phylogenetically distinct from the Mongolian and Indian strains (Type 2D) and the Korean and Japanese strains (Type 2A).Journal of molecular evolution · 2004Article
- Haplotypes in the dystrophin DNA segment point to a mosaic origin of modern human diversity.American journal of human genetics · 2003Article
- Features of evolution and expansion of modern humans, inferred from genomewide microsatellite markers.American journal of human genetics · 2003Article
- The genetic heritage of the earliest settlers persists both in Indian tribal and caste populations.American journal of human genetics · 2003Article
- Re-sequencing of multiple single nucleotide polymorphisms by liquid chromatography-electrospray ionization mass spectrometry.Nucleic acids research · 2002Article
- Extensive linkage disequilibrium in small human populations in Eurasia.American journal of human genetics · 2002Article
- The Eurasian heartland: a continental perspective on Y-chromosome diversity.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Global analysis of ATM polymorphism reveals significant functional constraint.American journal of human genetics · 2001Article
- A highly variable segment of human subterminal 16p reveals a history of population growth for modern humans outstide Africa.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- When did the human population size start increasing?Genetics · 2000Article
- Population genetic implications from sequence variation in four Y chromosome genes.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Distinctiveness of genotypes of Helicobacter pylori in Calcutta, India.Journal of bacteriology · 2000Article
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7 authors at 1 institution in 1 country.
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Abstract
Despite mounting genetic evidence implicating a recent origin of modern humans, the elucidation of early migratory gene-flow episodes remains incomplete. Geographic distribution of haplotypes may show traces of ancestral migrations. However, such evolutionary signatures can be erased easily by recombination and mutational perturbations. A 565-bp chromosome 21 region near the MX1 gene, which contains nine sites frequently polymorphic in human populations, has been found. It is unaffected by recombination and recurrent mutation and thus reflects only migratory history, genetic drift, and possibly selection. Geographic distribution of contemporary haplotypes implies distinctive prehistoric human migrations: one to Oceania, one to Asia and subsequently to America, and a third one predominantly to Europe. The findings with chromosome 21 are confirmed by independent evidence from a Y chromosome phylogeny. Loci of this type will help to decipher the evolutionary history of modern humans.
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