ArticleProceedings of the National Academy of Sciences of the United States of America1999
Regulation of p53 expression by thymidylate synthase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 120 citations in OpenAlex.
- The mTORC2 component SIN1 post-transcriptionally regulates TYMS levels and modulates P53 activity in response to 5-FU chemotherapy.Cell communication and signaling : CCS · 2026Article
- Article
- Metabolic reprogramming in colorectal cancer: regulatory networks and therapy.Cell & bioscience · 2023Review
- Targeting Thymidylate Synthase and tRNA-Derived Non-Coding RNAs Improves Therapeutic Sensitivity in Colorectal Cancer.Antioxidants (Basel, Switzerland) · 2022Article
- Detection of a G-Quadruplex as a Regulatory Element inInternational journal of molecular sciences · 2020Article
- Polymorphisms of SLC19A1 80 G>A, MTHFR 677 C>T, and Tandem TS Repeats Influence Pharmacokinetics, Acute Liver Toxicity, and Vomiting in Children With Acute Lymphoblastic Leukemia Treated With High Doses of Methotrexate.Frontiers in pediatrics · 2020Article
- Associations of MTRR and TSER polymorphisms related to folate metabolism with susceptibility to metabolic syndrome.Genes & genomics · 2019Article
- Expanding horizons: new roles for non-canonical RNA-binding proteins in cancer.Current opinion in genetics & development · 2018Review
- Modulation of the p53 family network by RNA-binding proteins.Translational cancer research · 2016Article
- The expanding regulatory universe of p53 in gastrointestinal cancer.F1000Research · 2016Review
- MiR-20a-5p represses multi-drug resistance in osteosarcoma by targeting the KIF26B gene.Cancer cell international · 2016Article
- Standing the test of time: targeting thymidylate biosynthesis in cancer therapy.Nature reviews. Clinical oncology · 2014Review
- Surgery for colorectal liver metastases: The evolution of determining prognosis.World journal of gastrointestinal oncology · 2013Review
- Thymidylate synthase gene polymorphism and survival of colorectal cancer patients receiving adjuvant 5-fluorouracil.Genetic testing and molecular biomarkers · 2013Article
- Flaviviruses are sensitive to inhibition of thymidine synthesis pathways.Journal of virology · 2013Article
- Prognostic significance of miR-215 in colon cancer.Clinical colorectal cancer · 2011Article
- Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- Translational control analysis by translationally active RNA capture/microarray analysis (TrIP-Chip).Nucleic acids research · 2010Article
- miRNAs as biomarkers in colorectal cancer diagnosis and prognosis.Bioanalysis · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Previous studies showed that thymidylate synthase (TS), as an RNA binding protein, regulates its own synthesis by impairing the translation of TS mRNA. In this report, we present evidence that p53 expression is affected in a similar manner by TS. For these studies, we used a TS-depleted human colon cancer HCT-C cell that had been transfected with either the human TS cDNA or the Escherichia coli TS gene. The level of p53 protein in transfected cells overexpressing human TS was significantly reduced when compared with its corresponding parent HCT-C cells. This suppression of p53 expression was the direct result of decreased translational efficiency of p53 mRNA. Similar results were obtained upon transfection of HCT-C cells with pcDNA 3.1 (+) containing the E. coli TS gene. These findings provide evidence that TS, from diverse species, specifically regulates p53 expression at the translational level. In addition, TS-overexpressing cells with suppressed levels of p53 are significantly impaired in their ability to arrest in G1 phase in response to exposure to a DNA-damaging agent such as gamma-irradiation. These studies provide support for the in vivo biological relevance of the interaction between TS and p53 mRNA and identify a molecular pathway for controlling p53 expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.