ArticleBiophysical journal1999
Monte Carlo simulation of two-component bilayers: DMPC/DSPC mixtures.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Interaction Energy between Two Separated Charged Spheres Surrounded Inside and Outside by Electrolyte.Membranes · 2022Article
- Dynamic "Molecular Portraits" of Biomembranes Drawn by Their Lateral Nanoscale Inhomogeneities.International journal of molecular sciences · 2021Review
- Cellular absorption of small molecules: free energy landscapes of melatonin binding at phospholipid membranes.Scientific reports · 2020Article
- Crowding-Induced Mixing Behavior of Lipid Bilayers: Examination of Mixing Energy, Phase, Packing Geometry, and Reversibility.Langmuir : the ACS journal of surfaces and colloids · 2016Article
- Article
- Phase separation and fluctuations in mixtures of a saturated and an unsaturated phospholipid.Biophysical journal · 2012Article
- A statistical mechanical model of cholesterol/phospholipid mixtures: linking condensed complexes, superlattices, and the phase diagram.Journal of the American Chemical Society · 2012Article
- Enhanced Lipid Diffusion and Mixing in Accelerated Molecular Dynamics.Journal of chemical theory and computation · 2011Article
- FCS diffusion laws in two-phase lipid membranes: determination of domain mean size by experiments and Monte Carlo simulations.Biophysical journal · 2011Article
- Simulation of the lo-ld phase boundary in DSPC/DOPC/cholesterol ternary mixtures using pairwise interactions.The journal of physical chemistry. B · 2011Article
- A simple thermodynamic model of the liquid-ordered state and the interactions between phospholipids and cholesterol.Biophysical journal · 2011Article
- Near-critical fluctuations and cytoskeleton-assisted phase separation lead to subdiffusion in cell membranes.Biophysical journal · 2011Article
- A liposomal formulation able to incorporate a high content of Paclitaxel and exert promising anticancer effect.Journal of drug delivery · 2011Article
- Raftlike mixtures of sphingomyelin and cholesterol investigated by solid-state 2H NMR spectroscopy.Journal of the American Chemical Society · 2008Article
- Investigation of domain formation in sphingomyelin/cholesterol/POPC mixtures by fluorescence resonance energy transfer and Monte Carlo simulations.Biophysical journal · 2007Article
- Diffusion in two-component lipid membranes--a fluorescence correlation spectroscopy and monte carlo simulation study.Biophysical journal · 2005Article
- Anomalous diffusion in a gel-fluid lipid environment: a combined solid-state NMR and obstructed random-walk perspective.Biophysical journal · 2004Article
- Temperature dependence of the surface topography in dimyristoylphosphatidylcholine/distearoylphosphatidylcholine multibilayers.Biophysical journal · 2004Article
- Lateral distribution of cholesterol in dioleoylphosphatidylcholine lipid bilayers: cholesterol-phospholipid interactions at high cholesterol limit.Biophysical journal · 2004Article
- The effect of lipid demixing on the electrostatic interaction of planar membranes across a salt solution.Biophysical journal · 2003Article
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3 authors.
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Abstract
In this paper, we describe a relatively simple lattice model of a two-component, two-state phospholipid bilayer. Application of Monte Carlo methods to this model permits simulation of the observed excess heat capacity versus temperature curves of dimyristoylphosphatidylcholine (DMPC)/distearoylphosphatidylcholine (DSPC) mixtures as well as the lateral distributions of the components and properties related to these distributions. The analysis of the bilayer energy distribution functions reveals that the gel-fluid transition is a continuous transition for DMPC, DSPC, and all DMPC/DSPC mixtures. A comparison of the thermodynamic properties of DMPC/DSPC mixtures with the configurational properties shows that the temperatures characteristics of the configurational properties correlate well with the maxima in the excess heat capacity curves rather than with the onset and completion temperatures of the gel-fluid transition. In the gel-fluid coexistence region, we also found excellent agreement between the threshold temperatures at different system compositions detected in fluorescence recovery after photobleaching experiments and the temperatures at which the percolation probability of the gel clusters is 0.36. At every composition, the calculated mole fraction of gel state molecules at the fluorescence recovery after photobleaching threshold is 0.34 and, at the percolation threshold of gel clusters, it is 0.24. The percolation threshold mole fraction of gel or fluid lipid depends on the packing geometry of the molecules and the interchain interactions. However, it is independent of temperature, system composition, and state of the percolating cluster.
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