ArticleBiophysical journal1999
An alamethicin channel in a lipid bilayer: molecular dynamics simulations.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed.
- Regulation of Peptaibol Profile by Velvet LAE1/VEL1 inMicroorganisms · 2026Article
- Structure of a barrel-stave pore formed by magainin-2 reveals anion selectivity and zipper-mediated assembly.Scientific reports · 2025Article
- Recent advances in the use of Trichoderma-containing multicomponent microbial inoculants for pathogen control and plant growth promotion.World journal of microbiology & biotechnology · 2024Review
- Design of ionic liquids containing glucose and choline as drug carriers, finding the link between QM and MD studies.Scientific reports · 2022Article
- Archaeal Lipids Regulating the Trimeric Structure Dynamics of Bacteriorhodopsin for Efficient Proton Release and Uptake.International journal of molecular sciences · 2022Article
- The structure of the antimicrobial human cathelicidin LL-37 shows oligomerization and channel formation in the presence of membrane mimics.Scientific reports · 2020Article
- Diversity of Linear Non-Ribosomal Peptide in Biocontrol Fungi.Journal of fungi (Basel, Switzerland) · 2020Review
- Energetics and mechanism of anion permeation across formate-nitrite transporters.Scientific reports · 2017Article
- Novel cationic lipid nanoparticles as an ophthalmic delivery system for multicomponent drugs: development, characterization, in vitro permeation, in vivo pharmacokinetic, and molecular dynamics studies.International journal of nanomedicine · 2017Article
- Simulations of Membrane-Disrupting Peptides I: Alamethicin Pore Stability and Spontaneous Insertion.Biophysical journal · 2016Article
- A Rapid and Quantitative Flow Cytometry Method for the Analysis of Membrane Disruptive Antimicrobial Activity.PloS one · 2016Article
- Multiscale modeling of droplet interface bilayer membrane networks.Biomicrofluidics · 2015Article
- Analysis of the flexibility and stability of the structure of magainin in a bilayer, and in aqueous and nonaqueous solutions using molecular dynamics simulations.Journal of molecular modeling · 2015Article
- Structural approaches to understanding retinal proteins needed for vision.Current opinion in cell biology · 2014Review
- A thermodynamic approach to alamethicin pore formation.Biochimica et biophysica acta · 2014Article
- Direct visualization of the alamethicin pore formed in a planar phospholipid matrix.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The dimerization interface of the glycoprotein Ibβ transmembrane domain corresponds to polar residues within a leucine zipper motif.Protein science : a publication of the Protein Society · 2011Article
- Antimicrobial peptides bind more strongly to membrane pores.Biochimica et biophysica acta · 2010Article
- Antimicrobial peptides in toroidal and cylindrical pores.Biochimica et biophysica acta · 2010Article
- Alamethicin in lipid bilayers: combined use of X-ray scattering and MD simulations.Biochimica et biophysica acta · 2009Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present the results of 2-ns molecular dynamics (MD) simulations of a hexameric bundle of Alm helices in a 1-palmitoyl-2-oleoylphosphatidylcholine bilayer. These simulations explore the dynamic properties of a model of a helix bundle channel in a complete phospholipid bilayer in an aqueous environment. We explore the stability and conformational dynamics of the bundle in a phospholipid bilayer. We also investigate the effect on bundle stability of the ionization state of the ring of Glu18 side chains. If all of the Glu18 side chains are ionised, the bundle is unstable; if none of the Glu18 side chains are ionized, the bundle is stable. pKA calculations suggest that either zero or one ionized Glu18 is present at neutral pH, correlating with the stable form of the helix bundle. The structural and dynamic properties of water in this model channel were examined. As in earlier in vacuo simulations (Breed et al., 1996 .Biophys. J. 70:1643-1661), the dipole moments of water molecules within the pore were aligned antiparallel to the helix dipoles. This contributes to the stability of the helix bundle.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.