ArticleAmerican journal of human genetics1999
A note on power approximations for the transmission/disequilibrium test.
Article in American journal of human genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia.Molecular psychiatry · 2005Trial
- PolyGEE: a generalized estimating equation approach to the efficient and robust estimation of polygenic effects in large-scale association studies.Biostatistics (Oxford, England) · 2018Article
- Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil: role of COL1A1.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2015Article
- Analytic power and sample size calculation for the genotypic transmission/disequilibrium test in case-parent trio studies.Biometrical journal. Biometrische Zeitschrift · 2014Article
- A genome-wide assessment of the role of untagged copy number variants in type 1 diabetes.PLoS genetics · 2014Article
- Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2012Article
- TCRBV20S1 polymorphism does not influence the susceptibility to type 1 diabetes and multiple sclerosis in the Sardinian population.Immunogenetics · 2012Article
- Genome-wide association study to identify the genetic determinants of otitis media susceptibility in childhood.PloS one · 2012Article
- Handling missing data in transmission disequilibrium test in nuclear families with one affected offspring.PloS one · 2012Article
- Genetic and functional evaluation of the role of CXCR1 and CXCR2 in susceptibility to visceral leishmaniasis in north-east India.BMC medical genetics · 2011Article
- FLI1 polymorphism affects susceptibility to cutaneous leishmaniasis in Brazil.Genes and immunity · 2011Article
- Genetic and functional evidence implicating DLL1 as the gene that influences susceptibility to visceral leishmaniasis at chromosome 6q27.The Journal of infectious diseases · 2011Article
- No evidence for association between SLC11A1 and visceral leishmaniasis in India.BMC medical genetics · 2011Article
- Evidence of association with type 1 diabetes in the SLC11A1 gene region.BMC medical genetics · 2011Article
- The power of the Transmission Disequilibrium Test in the presence of population stratification.European journal of human genetics : EJHG · 2010Article
- Evidence for associations between the purinergic receptor P2X(7) (P2RX7) and toxoplasmosis.Genes and immunity · 2010Article
- CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study.BMC medical genetics · 2010Article
- Sex chromosomes and genetic association studies.Genome medicine · 2009Article
- Myocilin polymorphisms and high myopia in subjects of European origin.Molecular vision · 2009Article
- Screening and replication using the same data set: testing strategies for family-based studies in which all probands are affected.PLoS genetics · 2008Article
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1 author.
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Abstract
The transmission/disequilibrium test (TDT) is a popular method for detection of the genetic basis of a disease. Investigators planning such studies require computation of sample size and power, allowing for a general genetic model. Here, a rigorous method is presented for obtaining the power approximations of the TDT for samples consisting of families with either a single affected child or affected sib pairs. Power calculations based on simulation show that these approximations are quite precise. By this method, it is also shown that a previously published power approximation of the TDT is erroneous.
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