ArticleAmerican journal of human genetics1999
mtDNA analysis of Nile River Valley populations: A genetic corridor or a barrier to migration?
Article in American journal of human genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
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- North and East African mitochondrial genetic variation needs further characterization towards precision medicine.Journal of advanced research · 2023Article
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- Dense sampling of ethnic groups within African countries reveals fine-scale genetic structure and extensive historical admixture.Science advances · 2023Article
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- Social stratification without genetic differentiation at the site of Kulubnarti in Christian Period Nubia.Nature communications · 2021Article
- Northeast African genomic variation shaped by the continuity of indigenous groups and Eurasian migrations.PLoS genetics · 2017Article
- Genetic Diversity and Population Structure of Ethiopian Sheep Populations Revealed by High-Density SNP Markers.Frontiers in genetics · 2017Article
- Mosaic maternal ancestry in the Great Lakes region of East Africa.Human genetics · 2015Article
- The genetics of East African populations: a Nilo-Saharan component in the African genetic landscape.Scientific reports · 2015Article
- Spatial and temporal simulation of human evolution. Methods, frameworks and applications.Current genomics · 2014Article
- Genetic variation and adaptation in Africa: implications for human evolution and disease.Cold Spring Harbor perspectives in biology · 2014Review
- The history of the North African mitochondrial DNA haplogroup U6 gene flow into the African, Eurasian and American continents.BMC evolutionary biology · 2014Article
- First insights into the metagenome of Egyptian mummies using next-generation sequencing.Journal of applied genetics · 2013Article
- Mitochondrial DNA diversity in two ethnic groups in southeastern Kenya: perspectives from the northeastern periphery of the Bantu expansion.American journal of physical anthropology · 2013Article
- The influence of habitats on female mobility in Central and Western Africa inferred from human mitochondrial variation.BMC evolutionary biology · 2013Article
- Introducing the Algerian mitochondrial DNA and Y-chromosome profiles into the North African landscape.PloS one · 2013Article
- Indian signatures in the westernmost edge of the European Romani diaspora: new insight from mitogenomes.PloS one · 2013Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To assess the extent to which the Nile River Valley has been a corridor for human migrations between Egypt and sub-Saharan Africa, we analyzed mtDNA variation in 224 individuals from various locations along the river. Sequences of the first hypervariable segment (HV1) of the mtDNA control region and a polymorphic HpaI site at position 3592 allowed us to designate each mtDNA as being of "northern" or "southern" affiliation. Proportions of northern and southern mtDNA differed significantly between Egypt, Nubia, and the southern Sudan. At slowly evolving sites within HV1, northern-mtDNA diversity was highest in Egypt and lowest in the southern Sudan, and southern-mtDNA diversity was highest in the southern Sudan and lowest in Egypt, indicating that migrations had occurred bidirectionally along the Nile River Valley. Egypt and Nubia have low and similar amounts of divergence for both mtDNA types, which is consistent with historical evidence for long-term interactions between Egypt and Nubia. Spatial autocorrelation analysis demonstrates a smooth gradient of decreasing genetic similarity of mtDNA types as geographic distance between sampling localities increases, strongly suggesting gene flow along the Nile, with no evident barriers. We conclude that these migrations probably occurred within the past few hundred to few thousand years and that the migration from north to south was either earlier or lesser in the extent of gene flow than the migration from south to north.
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